Molecular analysis of aquaporin genes 1 to 4 in patients with Menière's disease

Candreia, Claudia; Schmuziger, Nicolas; Gürtler, Nicolas (2010). Molecular analysis of aquaporin genes 1 to 4 in patients with Menière's disease. Cellular physiology and biochemistry, 26(4-5), pp. 787-92. Basel: Karger 10.1159/000322346

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Menière's Disease (MD) is an episodic cochleovestibular dysfunction of unknown etiology, still lacking a specific test and therapy. The proposed theories on the pathophysiology include genetic factors and factors relating to inner ear homeostasis. Various aquaporins (AQP), water channels, expressed in the inner ear and the vestibular organ, are involved in homeostasis. Mutations in AQP genes could result in disturbed inner ear homeostasis and endolymphatic hydrops, and therefore be involved in the pathogenesis of MD. Aim: To search for mutations in AQP1 to 4 in patients suffering from MD.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)

UniBE Contributor:

Candreia, Claudia

ISSN:

1015-8987

Publisher:

Karger

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:10

Last Modified:

04 May 2014 23:05

Publisher DOI:

10.1159/000322346

PubMed ID:

21063116

Web of Science ID:

000283859000030

URI:

https://boris.unibe.ch/id/eprint/1500 (FactScience: 203207)

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