Non-antibiotic treatment of bacterial vaginosis-a systematic review.

Tidbury, Fiona Damaris; Langhart, Anita; Weidlinger, Susanna; Stute, Petra (2021). Non-antibiotic treatment of bacterial vaginosis-a systematic review. Archives of gynecology and obstetrics, 303(1), pp. 37-45. Springer-Verlag 10.1007/s00404-020-05821-x

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PURPOSE

Bacterial vaginosis (BV) is one of the most common vaginal complaints of women of reproductive age, characterized by a shift from a Lactobacillus-dominated vaginal microbiome towards a more diverse flora of facultative and obligately anaerobic bacteria. BV can increase the risk of preterm births, contracting sexually transmitted infections and developing other chronic health issues. Standard treatment for BV are antibiotics, however despite initial efficacy, they do not provide effective long-term treatment and recurrence or persistence prevention. This systematic review focuses on describing the current study situation and summarizing the newest data on the efficacy of alternative non-antibiotic options, namely probiotic products containing lactobacilli, lactic acid, sucrose gel, combination products with estriol, and supplementation of antibiotics.

METHODS

We conducted a systematic literature search using the MEDLINE database and evaluated the 33 trials which met our inclusion criteria.

CONCLUSION

The diverse study designs produced extremely varied outcomes, but so far the results are promising. Furthermore, these alternatives have shown little to no adverse effects and are consequently generally considered safe to use. In general, the results of this review warrant more thorough trials with larger cohort sizes to provide sufficient evidence for these alternatives to be a part of official treatment recommendations.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Weidlinger, Susanna and Stute, Petra

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0932-0067

Publisher:

Springer-Verlag

Language:

English

Submitter:

Monika Zehr

Date Deposited:

13 Jan 2021 09:42

Last Modified:

04 Feb 2021 01:34

Publisher DOI:

10.1007/s00404-020-05821-x

PubMed ID:

33025086

Uncontrolled Keywords:

Bacterial vaginosis Lactobacillus Probiotics Treatment

BORIS DOI:

10.48350/150150

URI:

https://boris.unibe.ch/id/eprint/150150

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