The impact of menopausal hormone therapy on overall mortality - a comprehensive review.

Stute, P.; Stadler, A; Heufelder, A (2020). The impact of menopausal hormone therapy on overall mortality - a comprehensive review. Climacteric, 23(5), pp. 447-459. Informa Healthcare 10.1080/13697137.2020.1767568

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Menopausal hormone therapy (MHT) is indicated for menopausal symptom relief. However, MHT has also been shown to be beneficial for prevention of long-term estrogen deficiency sequelae including mortality. Based on a comprehensive literature review on MHT and mortality, the authors' recommendations are as follows: in postmenopausal women, MHT appears to confer a (significant) reduction in overall mortality; the benefit especially applies to women who initiate long-term MHT early after menopause; in women with prevalent cardiovascular risk factors (except for diabetes mellitus, where results are mixed), the benefit of MHT on overall mortality is even more pronounced; and, however, study results are difficult to compare due to heterogeneous study designs.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Stute, Petra

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1369-7137

Publisher:

Informa Healthcare

Language:

English

Submitter:

Monika Zehr

Date Deposited:

13 Jan 2021 10:03

Last Modified:

13 Jan 2021 10:03

Publisher DOI:

10.1080/13697137.2020.1767568

PubMed ID:

32552066

Uncontrolled Keywords:

Menopausal hormone therapy age at initiation overall mortality review treatment duration

URI:

https://boris.unibe.ch/id/eprint/150156

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