Practice patterns related to prostate cancer grading: results of a 2019 Genitourinary Pathology Society clinician survey.

Fine, Samson W; Trpkov, Kiril; Amin, Mahul B; Algaba, Ferran; Aron, Manju; Baydar, Dilek E; Beltran, Antonio Lopez; Brimo, Fadi; Cheville, John C; Colecchia, Maurizio; Comperat, Eva; Costello, Tony; da Cunha, Isabela Werneck; Delprado, Warick; DeMarzo, Angelo M; Giannico, Giovanna A; Gordetsky, Jennifer B; Guo, Charles C; Hansel, Donna E; Hirsch, Michelle S; ... (2021). Practice patterns related to prostate cancer grading: results of a 2019 Genitourinary Pathology Society clinician survey. Urologic oncology, 39(5), 295.e1-295.e8. Elsevier 10.1016/j.urolonc.2020.08.027

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PURPOSE

To survey urologic clinicians regarding interpretation of and practice patterns in relation to emerging aspects of prostate cancer grading, including quantification of high-grade disease, cribriform/intraductal carcinoma, and impact of magnetic resonance imaging-targeted needle biopsy.

MATERIALS AND METHODS

The Genitourinary Pathology Society distributed a survey to urology and urologic oncology-focused societies and hospital departments. Eight hundred and thirty four responses were collected and analyzed using descriptive statistics.

RESULTS

Eighty percent of survey participants use quantity of Gleason pattern 4 on needle biopsy for clinical decisions, less frequently with higher Grade Groups. Fifty percent interpret "tertiary" grade as a minor/<5% component. Seventy percent of respondents would prefer per core grading as well as a global/overall score per set of biopsies, but 70% would consider highest Gleason score in any single core as the grade for management. Seventy five percent utilize Grade Group terminology in patient discussions. For 45%, cribriform pattern would affect management, while for 70% the presence of intraductal carcinoma would preclude active surveillance.

CONCLUSION

This survey of practice patterns in relationship to prostate cancer grading highlights similarities and differences between contemporary pathology reporting and its clinical application. As utilization of Gleason pattern 4 quantification, minor tertiary pattern, cribriform/intraductal carcinoma, and the incorporation of magnetic resonance imaging-based strategies evolve, these findings may serve as a basis for more nuanced communication and guide research efforts involving pathologists and clinicians.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Präzisionsonkologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Präzisionsonkologie

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)

UniBE Contributor:

Rubin, Mark Andrew

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1873-2496

Publisher:

Elsevier

Language:

English

Submitter:

Marla Rittiner

Date Deposited:

29 Dec 2020 09:36

Last Modified:

26 May 2021 01:32

Publisher DOI:

10.1016/j.urolonc.2020.08.027

PubMed ID:

32948433

Uncontrolled Keywords:

Active surveillance Cribriform Grading MRI Prostate cancer

BORIS DOI:

10.48350/150191

URI:

https://boris.unibe.ch/id/eprint/150191

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