Impact of Lineage Plasticity to and from a Neuroendocrine Phenotype on Progression and Response in Prostate and Lung Cancers.

Rubin, Mark A.; Bristow, Robert G; Thienger, Phillip D.; Dive, Caroline; Imielinski, Marcin (2020). Impact of Lineage Plasticity to and from a Neuroendocrine Phenotype on Progression and Response in Prostate and Lung Cancers. Molecular cell, 80(4), pp. 562-577. Cell Press 10.1016/j.molcel.2020.10.033

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Intratumoral heterogeneity can occur via phenotype transitions, often after chronic exposure to targeted anticancer agents. This process, termed lineage plasticity, is associated with acquired independence to an initial oncogenic driver, resulting in treatment failure. In non-small cell lung cancer (NSCLC) and prostate cancers, lineage plasticity manifests when the adenocarcinoma phenotype transforms into neuroendocrine (NE) disease. The exact molecular mechanisms involved in this NE transdifferentiation remain elusive. In small cell lung cancer (SCLC), plasticity from NE to nonNE phenotypes is driven by NOTCH signaling. Herein we review current understanding of NE lineage plasticity dynamics, exemplified by prostate cancer, NSCLC, and SCLC.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Präzisionsonkologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Präzisionsonkologie

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)

UniBE Contributor:

Rubin, Mark Andrew and Thienger, Phillip Dominik

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1097-2765

Publisher:

Cell Press

Language:

English

Submitter:

Marla Rittiner

Date Deposited:

28 Dec 2020 18:46

Last Modified:

01 Mar 2021 15:14

Publisher DOI:

10.1016/j.molcel.2020.10.033

PubMed ID:

33217316

Additional Information:

Review (LS, 26.2.21)

BORIS DOI:

10.48350/150214

URI:

https://boris.unibe.ch/id/eprint/150214

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