Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review.

Coca-Pelaz, Andrés; Shah, Jatin P; Hernandez-Prera, Juan C; Ghossein, Ronald A; Rodrigo, Juan P; Hartl, Dana M; Olsen, Kerry D; Shaha, Ashok R; Zafereo, Mark; Suarez, Carlos; Nixon, Iain J; Randolph, Gregory W; Mäkitie, Antti A; Kowalski, Luiz P; Vander Poorten, Vincent; Sanabria, Alvaro; Guntinas-Lichius, Orlando; Simo, Ricard; Zbären, Peter; Angelos, Peter; ... (2020). Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review. Advances in therapy, 37(7), pp. 3112-3128. Springer 10.1007/s12325-020-01391-1

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INTRODUCTION

Aggressive variants of papillary thyroid cancer (PTC) have been described with increasing frequency. These variants include diffuse sclerosing variant, tall cell variant, columnar cell variant, solid variant, and hobnail variant.

METHODS

We have performed a review of the more aggressive variants of PTC with respect to main characteristics, histological and molecular features, and the consequences that the knowledge of these variants should have in the treatment of the patients.

RESULTS

At the present time, we do not know the prognostic value of these aggressive PTC variants. The extent of the surgical treatment and adjuvant therapy necessary should be decided on the basis of the extent of the tumor at presentation and the opinion of experienced clinicians.

CONCLUSION

These aggressive variants should be known by clinicians, to avoid underdiagnosis, and treated according to the latest recommendations in the literature.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)

UniBE Contributor:

Zbären, Peter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0741-238X

Publisher:

Springer

Language:

English

Submitter:

Stefan Weder

Date Deposited:

19 Jan 2021 12:29

Last Modified:

19 Jan 2021 12:38

Publisher DOI:

10.1007/s12325-020-01391-1

PubMed ID:

32488657

Uncontrolled Keywords:

Aggressive variants papillary thyroid cancer Columnar cell variant Diffuse sclerosis variant Hobnail variant Solid variant Tall cell variant

BORIS DOI:

10.48350/150347

URI:

https://boris.unibe.ch/id/eprint/150347

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