Azo-propofols: photochromic potentiators of GABA(A) receptors

Stein, Marco; Middendorp, Simon J; Carta, Valentina; Pejo, Ervin; Raines, Douglas E; Forman, Stuart A; Sigel, Erwin; Trauner, Dirk (2012). Azo-propofols: photochromic potentiators of GABA(A) receptors. Angewandte Chemie (International ed.), 51(42), pp. 10500-4. Weinheim: Wiley-VCH 10.1002/anie.201205475

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Shine and rise! GABA(A) receptors are ligand-gated chloride ion channels that respond to γ-aminobutyric acid (GABA), which is the major inhibitory neurotransmitter of the mammalian central nervous system. Azobenzene derivatives of propofol, such as compound 1 (see scheme), increase GABA-induced currents in the dark form and lose this property upon light exposure and thus function as photochromic potentiators. Compound 1 can be employed as a light-dependent general anesthetic in translucent tadpoles.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Middendorp, Simon, Carta, Valentina, Sigel, Erwin

ISSN:

1433-7851

Publisher:

Wiley-VCH

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:37

Last Modified:

05 Dec 2022 14:11

Publisher DOI:

10.1002/anie.201205475

PubMed ID:

22968919

Web of Science ID:

000309745600011

URI:

https://boris.unibe.ch/id/eprint/15040 (FactScience: 222194)

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