Hasler, Gregor; Suker, Samir; Schoretsanitis, Georgios; Mihov, Yoan (2020). Sustained Improvement of Negative Self-Schema After a Single Ketamine Infusion: An Open-Label Study. Frontiers in neuroscience, 14(687), p. 687. Frontiers Research Foundation 10.3389/fnins.2020.00687
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Conventional antidepressants have several important limitations, including a lack of direct effects on negative self-schema, which is at the core of Beck’s cognitive theory of depression. Based on previous studies showing a positive effect of ketamine on negative cognition, we compared reductions in negative self-schema between responders and non-responders to a single infusion of ketamine. In an open-label study, 26 participants with treatment-resistant depression received 0.5 mg/kg ketamine via infusion. Depression symptoms were assessed at baseline, 24 h, and 7 days after treatment with Montgomery-Åsberg Depression Rating Scale (MADRS) and Beck Depression Inventory (BDI-II). Nine of the 26 participants fulfilled response criteria after 24 h. Of these, eight still fulfilled response criteria after 7 days. Response was defined as a reduction in MADRS total score of 50% or more. Responders improved significantly more than non-responders both 24 h and 7 days after ketamine treatment on the following BDI-II items: item 1 (“Sadness”), item 7 (“Self-Dislike”), and item 8 (“Self- Criticalness”). These results suggest an important therapeutic effect of ketamine on negative self-schema, which is a fundamental cognitive aspect of depression. This effect is unique and might be associated with ketamine’s profound effects on neuroplasticity. Small sample size and lack of a placebo control group are the major limitations of this study.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy |
UniBE Contributor: |
Hasler, Gregor, Suker Al-Ghazali, Samir, Mihov, Yoan Venceslavov |
Subjects: |
500 Science > 570 Life sciences; biology |
ISSN: |
1662-4548 |
Publisher: |
Frontiers Research Foundation |
Language: |
English |
Submitter: |
Samir Suker Al-Ghazali |
Date Deposited: |
14 Jan 2021 10:05 |
Last Modified: |
02 Mar 2023 23:34 |
Publisher DOI: |
10.3389/fnins.2020.00687 |
PubMed ID: |
32714138 |
BORIS DOI: |
10.48350/150483 |
URI: |
https://boris.unibe.ch/id/eprint/150483 |
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