Sustained Improvement of Negative Self-Schema After a Single Ketamine Infusion: An Open-Label Study

Hasler, Gregor; Suker, Samir; Schoretsanitis, Georgios; Mihov, Yoan (2020). Sustained Improvement of Negative Self-Schema After a Single Ketamine Infusion: An Open-Label Study. Frontiers in neuroscience, 14(687), p. 687. Frontiers Research Foundation 10.3389/fnins.2020.00687

[img]
Preview
Text
fnins-14-00687.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (897kB) | Preview

Conventional antidepressants have several important limitations, including a lack of direct effects on negative self-schema, which is at the core of Beck’s cognitive theory of depression. Based on previous studies showing a positive effect of ketamine on negative cognition, we compared reductions in negative self-schema between responders and non-responders to a single infusion of ketamine. In an open-label study, 26 participants with treatment-resistant depression received 0.5 mg/kg ketamine via infusion. Depression symptoms were assessed at baseline, 24 h, and 7 days after treatment with Montgomery-Åsberg Depression Rating Scale (MADRS) and Beck Depression Inventory (BDI-II). Nine of the 26 participants fulfilled response criteria after 24 h. Of these, eight still fulfilled response criteria after 7 days. Response was defined as a reduction in MADRS total score of 50% or more. Responders improved significantly more than non-responders both 24 h and 7 days after ketamine treatment on the following BDI-II items: item 1 (“Sadness”), item 7 (“Self-Dislike”), and item 8 (“Self- Criticalness”). These results suggest an important therapeutic effect of ketamine on negative self-schema, which is a fundamental cognitive aspect of depression. This effect is unique and might be associated with ketamine’s profound effects on neuroplasticity. Small sample size and lack of a placebo control group are the major limitations of this study.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy

UniBE Contributor:

Hasler, Gregor; Suker Al-Ghazali, Samir and Mihov, Yoan

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

1662-4548

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Samir Suker Al-Ghazali

Date Deposited:

14 Jan 2021 10:05

Last Modified:

17 Jan 2021 02:55

Publisher DOI:

10.3389/fnins.2020.00687

PubMed ID:

32714138

BORIS DOI:

10.48350/150483

URI:

https://boris.unibe.ch/id/eprint/150483

Actions (login required)

Edit item Edit item
Provide Feedback