The role of CD23 in the regulation of allergic responses.

Engeroff, Paul; Vogel, Monique (2021). The role of CD23 in the regulation of allergic responses. Allergy, 76(7), pp. 1981-1989. Wiley 10.1111/all.14724

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IgE, the key molecule in atopy has been shown to bind two receptors, FcεRI, the high-affinity receptor, and FcεRII (CD23), mostly found on B cells and that binds IgE with lower affinity. Whereas cross-linking of IgE on FcεRI triggers the allergic reaction, binding of IgE to CD23 playsan important role in both IgEregulation and presentation. Furthermore,IgE-immune complexes on B cells enhance antibody and T cell responses in mice and humans. However, the mechanisms that regulate the targeting of the two receptors and the respective function of the two pathways in inflammation or homeostasis are still a matter of debate. Here, we focus onCD23 and discuss several mechanisms related to IgE binding, as well as the impact of the IgE/antigen-binding on different immune cells expressing CD23. One recent paper has shown that free IgE preferentially binds to FcεRI whereas IgE immune complexes (IgE-ICs) are preferentially captured by CD23. Binding of IgE-ICs to CD23 on B cells can, on one hand, regulate serum IgE and prevent effector cell activation and on the other hand facilitate antigen presentation by delivering the antigen to dendritic cells. These data argue fora multifunctional role of CD23 for modulating IgEresponses.

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