Conjunctival cancer in people living with HIV.

Muchengeti, Mazvita; Bohlius, Julia; Dhokotera, Tafadzwa G (2021). Conjunctival cancer in people living with HIV. Current opinion in infectious diseases, 34(1), pp. 1-7. Wolters Kluwer Lippincott Williams & Wilkins 10.1097/QCO.0000000000000705

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PURPOSE OF REVIEW

Historically, conjunctival cancer has been associated with HIV particularly in sub-Saharan Africa. The human papilloma virus (HPV) has been implicated as a potential causative agent without conclusive evidence. This review covers recent evidence of the epidemiology, diagnosis and treatment of conjunctival cancer in people living with HIV (PLWH).

RECENT FINDINGS

HIV infection has been attributed to 33% of squamous cell carcinoma of the conjunctiva in sub-Saharan Africa. Although clear evidence of the effect of immunodeficiency on conjunctival cancer risk has been demonstrated, the role of HPV on conjunctival cancer development is still unclear. Biomarkers such as the p16 protein are not always indicative of HPV infection. The Epstein-Barr virus (EBV) might potentially be another infectious agent of interest in the development of conjunctival cancer. There is some evidence of increased conjunctival cancer recurrence post treatment as well as increased probability of metastasis in PLWH.

SUMMARY

Immunodeficiency increases the risk of conjunctival cancer in PLWH. Symptomatic screening of conjunctival cancer in PLWH should be encouraged. Research on HPV involvement should remain a priority and EBV considered as another etiologic agent of interest. More studies on treatment modalities in PLWH should be considered.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Bohlius, Julia Friederike and Dhokotera, Tafadzwa Gladys

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0951-7375

Publisher:

Wolters Kluwer Lippincott Williams & Wilkins

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

04 Jan 2021 19:31

Last Modified:

04 Jan 2021 21:33

Publisher DOI:

10.1097/QCO.0000000000000705

PubMed ID:

33337616

BORIS DOI:

10.48350/150617

URI:

https://boris.unibe.ch/id/eprint/150617

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