Desynchronization of temporal lobe theta-band activity during effective anterior thalamus deep brain stimulation in epilepsy.

Scherer, Maximillian; Milosevic, Luka; Guggenberger, Robert; Maus, Volker; Naros, Georgios; Grimm, Florian; Bucurenciu, Iancu; Steinhoff, Bernhard J; Weber, Yvonne G; Lerche, Holger; Weiss, Daniel; Rona, Sabine; Gharabaghi, Alireza (2020). Desynchronization of temporal lobe theta-band activity during effective anterior thalamus deep brain stimulation in epilepsy. NeuroImage, 218, p. 116967. Elsevier 10.1016/j.neuroimage.2020.116967

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BACKGROUND

Bilateral cyclic high frequency deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) reduces the seizure count in a subset of patients with epilepsy. Detecting stimulation-induced alterations of pathological brain networks may help to unravel the underlying physiological mechanisms related to effective stimulation delivery and optimize target engagement.

METHODS

We acquired 64-channel electroencephalography during ten ANT-DBS cycles (145 ​Hz, 90 ​μs, 3-5 ​V) of 1-min ON followed by 5-min OFF stimulation to detect changes in cortical activity related to seizure reduction. The study included 14 subjects (three responders, four non-responders, and seven healthy controls). Mixed-model ANOVA tests were used to compare differences in cortical activity between subgroups both ON and OFF stimulation, while investigating frequency-specific effects for the seizure onset zones.

RESULTS

ANT-DBS had a widespread desynchronization effect on cortical theta and alpha band activity in responders, but not in non-responders. Time domain analysis showed that the stimulation induced reduction in theta-band activity was temporally linked to the stimulation period. Moreover, stimulation induced theta-band desynchronization in the temporal lobe channels correlated significantly with the therapeutic response. Responders to ANT-DBS and healthy-controls had an overall lower level of theta-band activity compared to non-responders.

CONCLUSION

This study demonstrated that temporal lobe channel theta-band desynchronization may be a predictive physiological hallmark of therapeutic response to ANT-DBS and may be used to improve the functional precision of this intervention by verifying implantation sites, calibrating stimulation contacts, and possibly identifying treatment responders prior to implantation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Rona, Sabine

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1053-8119

Publisher:

Elsevier

Language:

English

Submitter:

Anette van Dorland

Date Deposited:

20 Jan 2021 14:47

Last Modified:

05 Dec 2022 15:43

Publisher DOI:

10.1016/j.neuroimage.2020.116967

PubMed ID:

32445879

Uncontrolled Keywords:

Anterior nucleus of the thalamus Biomarker Deep brain stimulation Electroencephalography Epilepsy

BORIS DOI:

10.48350/150622

URI:

https://boris.unibe.ch/id/eprint/150622

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