Scherer, Maximillian; Milosevic, Luka; Guggenberger, Robert; Maus, Volker; Naros, Georgios; Grimm, Florian; Bucurenciu, Iancu; Steinhoff, Bernhard J; Weber, Yvonne G; Lerche, Holger; Weiss, Daniel; Rona, Sabine; Gharabaghi, Alireza (2020). Desynchronization of temporal lobe theta-band activity during effective anterior thalamus deep brain stimulation in epilepsy. NeuroImage, 218, p. 116967. Elsevier 10.1016/j.neuroimage.2020.116967
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BACKGROUND
Bilateral cyclic high frequency deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) reduces the seizure count in a subset of patients with epilepsy. Detecting stimulation-induced alterations of pathological brain networks may help to unravel the underlying physiological mechanisms related to effective stimulation delivery and optimize target engagement.
METHODS
We acquired 64-channel electroencephalography during ten ANT-DBS cycles (145 Hz, 90 μs, 3-5 V) of 1-min ON followed by 5-min OFF stimulation to detect changes in cortical activity related to seizure reduction. The study included 14 subjects (three responders, four non-responders, and seven healthy controls). Mixed-model ANOVA tests were used to compare differences in cortical activity between subgroups both ON and OFF stimulation, while investigating frequency-specific effects for the seizure onset zones.
RESULTS
ANT-DBS had a widespread desynchronization effect on cortical theta and alpha band activity in responders, but not in non-responders. Time domain analysis showed that the stimulation induced reduction in theta-band activity was temporally linked to the stimulation period. Moreover, stimulation induced theta-band desynchronization in the temporal lobe channels correlated significantly with the therapeutic response. Responders to ANT-DBS and healthy-controls had an overall lower level of theta-band activity compared to non-responders.
CONCLUSION
This study demonstrated that temporal lobe channel theta-band desynchronization may be a predictive physiological hallmark of therapeutic response to ANT-DBS and may be used to improve the functional precision of this intervention by verifying implantation sites, calibrating stimulation contacts, and possibly identifying treatment responders prior to implantation.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine |
UniBE Contributor: |
Rona, Sabine |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1053-8119 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
20 Jan 2021 14:47 |
Last Modified: |
05 Dec 2022 15:43 |
Publisher DOI: |
10.1016/j.neuroimage.2020.116967 |
PubMed ID: |
32445879 |
Uncontrolled Keywords: |
Anterior nucleus of the thalamus Biomarker Deep brain stimulation Electroencephalography Epilepsy |
BORIS DOI: |
10.48350/150622 |
URI: |
https://boris.unibe.ch/id/eprint/150622 |
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