Normal values of the pulmonary artery acceleration time (PAAT) and the right ventricular ejection time (RVET) in children and adolescents and the impact of the PAAT/RVET-index in the assessment of pulmonary hypertension.

Habash, Sheeraz; Laser, Kai Thorsten; Moosmann, Julia; Reif, Roland; Adler, Werner; Glöckler, Martin; Kececioglu, Deniz; Dittrich, Sven (2019). Normal values of the pulmonary artery acceleration time (PAAT) and the right ventricular ejection time (RVET) in children and adolescents and the impact of the PAAT/RVET-index in the assessment of pulmonary hypertension. The international journal of cardiovascular imaging, 35(2), pp. 295-306. Springer 10.1007/s10554-019-01540-w

[img] Text
Habash2019_Article_NormalValuesOfThePulmonaryArte.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (2MB) | Request a copy

New echocardiographic modalities including pulmonary artery acceleration time (PAAT) and right ventricular ejection time (RVET) are evolving to facilitate an early non-invasive diagnosis for pulmonary hypertension (PH) in adults. In children, PAAT depends on age, body surface area (BSA) and heart rate (HR) and is used to predict PH. Normal values of RVET and their role to predict PH in children are still missing. PAAT/RVET-index correlates negatively with PH. We hypothesized that this index is a good predictor for PH in children and adolescents independent of age, BSA and HR and RVET is significantly reduced in PH. PAAT and RVET of 401 healthy children and 30 PH-patients were measured using pulsed-wave-Doppler. PH was diagnosed in PH-group invasively. PAAT/RVET-index for both groups was calculated. Sensitivity and specificity in prediction of PH of PAAT, PAAT z-score and PAAT/RVET-index were compared. We demonstrated normal values of RVET in children. In the healthy group, PAAT and RVET correlated significant positive to age (p < 0.001), and BSA (p < 0.001) and negative to HR (p < 0.001). PAAT/RVET-index correlated weakly to age, BSA and HR (p < 0.001). Mean pulmonary artery pressure (PAPM) ranged in the PH-group from 27 to 82 mmHg (mean 44 mmHg). In predicting PH, RVET is significantly reduced (p < 0.001). Comparing area under the curve (AUC), the difference between sensitivity and specificity of PAAT/RVET-index < 0.29 and calculated PAAT cut-off-point (87 ms) was significant (p < 0.001). Equally, AUC comparison between PAAT/RVET-index < 0.29 and PAAT z-score of - 1.33 was significant (p = 0.008). PAAT/RVET-index < 0.29 represents a good predictor of PH with a 100% sensitivity and a 95.8% specificity. PAAT/RVET-index is a simple tool and facilitates prediction of PH independent from z-scores.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Glöckler, Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1875-8312

Publisher:

Springer

Language:

English

Submitter:

Martin Glöckler

Date Deposited:

04 Feb 2021 15:53

Last Modified:

04 Feb 2021 16:00

Publisher DOI:

10.1007/s10554-019-01540-w

PubMed ID:

30689192

Uncontrolled Keywords:

Children Doppler Pulmonary artery acceleration time Pulmonary hypertension Right ventricular ejection time

BORIS DOI:

10.48350/150640

URI:

https://boris.unibe.ch/id/eprint/150640

Actions (login required)

Edit item Edit item
Provide Feedback