A mouse model for microbeam radiotherapy of the lung

Schültke, Elisabeth; Bayat, Sam; Bartzsch, Stefan; Bräuer-Krisch, Elke; Djonov, Valentin; Fiedler, Stefan; Fernandez-Palomo, Cristian; Jaekel, Felix; Pellicioli, Paolo; Trappetti, Verdiana; Hildebrandt, Guido (2021). A mouse model for microbeam radiotherapy of the lung. International journal of radiation oncology, biology, physics, 110(2), pp. 521-525. Elsevier 10.1016/j.ijrobp.2020.12.030

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Purpose
Radiotherapy is an important treatment component for patients with lung cancer. However, the survival time gained with clinical radiotherapy techniques is relatively short.

Data from pre-clinical experiments suggest that synchrotron microbeam radiotherapy (MRT) could be much better suited to control malignant brain tumours than current clinical concepts of radiotherapy. Even at peak doses of several hundred Gy, the extent of functional deficits is amazingly low.

Methods and Materials
We have developed the first mouse model to study the effects of microbeam irradiation in lung tissue.

Results
Up to peak doses of 400 Gy, no acute adverse effects were seen.

Conclusion
This model is well suited to explore the potential of MRT in the treatment of lung cancer, the response of normal lung tissue and organs of risk.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Djonov, Valentin Georgiev; Fernandez Palomo, Cristian Gabriel and Trappetti, Verdiana

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0360-3016

Publisher:

Elsevier

Language:

English

Submitter:

Benoît Zuber

Date Deposited:

21 Jan 2021 10:00

Last Modified:

16 May 2021 01:32

Publisher DOI:

10.1016/j.ijrobp.2020.12.030

PubMed ID:

33383127

BORIS DOI:

10.48350/150732

URI:

https://boris.unibe.ch/id/eprint/150732

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