The mannose 6-phosphate receptor targeted with porphyrin-based periodic mesoporous organosilica nanoparticles for rhabdomyosarcoma theranostics.

Daurat, Morgane; Nguyen, Christophe; Dominguez Gil, Sofia; Sol, Vincent; Chaleix, Vincent; Charnay, Clarence; Raehm, Laurence; El Cheikh, Khaled; Morère, Alain; Bernasconi, Michele; Timpanaro, Andrea; Garcia, Marcel; Cunin, Frédérique; Roessler, Jochen; Durand, Jean-Olivier; Gary-Bobo, Magali (2020). The mannose 6-phosphate receptor targeted with porphyrin-based periodic mesoporous organosilica nanoparticles for rhabdomyosarcoma theranostics. Biomaterials science, 8(13), pp. 3678-3684. Royal Society of Chemistry 10.1039/d0bm00586j

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Porphyrin-based periodic mesoporous organosilica nanoparticles (PMO) synthesized from a large functional octatriethoxysilylated porphyrin precursor and allowing two-photon excitation photodynamic therapy (TPE-PDT) and NIR imaging were synthesized. These PMO were grafted with polyethylene glycol (PEG) moieties and an analogue of mannose 6-phosphate functionalized at the anomeric position (AMFA). AMFAs are known to efficiently target mannose 6-phosphate receptors (M6PRs) which are over-expressed in various cancers. Here, we demonstrated for the first time that M6PRs were over-expressed in rhabdomyosarcoma (RMS) cells and could be efficiently targeted with PMO-AMFA allowing TPE imaging and TPE-PDT of RMS cells. The comparison with healthy myoblasts demonstrated an absence of biological effects, suggesting a cancer cell specificity in the biomedical action observed.

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