An endovascular assisted, nonocclusive cerebral bypass: a technical feasibility study in a rabbit model.

Spiessberger, Alexander; Strange, Fabio; Gruter, Basil Erwin; Wanderer, Stefan; Casoni, Daniela; Gruber, Philipp; Diepers, Michael; Remonda, Luca; Fandino, Javier; Añon, Javier; Marbacher, Serge (2020). An endovascular assisted, nonocclusive cerebral bypass: a technical feasibility study in a rabbit model. (In Press). Journal of neurosurgery, pp. 1-6. American Association of Neurological Surgeons 10.3171/2020.3.JNS20334

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OBJECTIVE

Temporary parent vessel occlusion performed to establish a high-flow interpositional bypass carries the risk of infarcts. The authors investigated the feasibility of a novel technique to establish a high-flow bypass without temporary parent vessel occlusion in order to lower the risk of ischemic complications.

METHODS

In 10 New Zealand white rabbits, a carotid artery side-to-end anastomosis was performed under parent artery patency with a novel endovascular balloon device. Intraoperative angiography, postoperative neurological assessments, and postoperative MRI/MRA were performed to evaluate the feasibility and safety of the novel technique.

RESULTS

A patent anastomosis was established in 10 of 10 animals; 3 procedure-related complications occurred. No postoperative focal neurological deficits were observed. The MRI/MRA findings include no infarcts and bypass patency in 50% of the animals.

CONCLUSIONS

The authors demonstrated the feasibility of an endovascular assisted, nonocclusive high-flow bypass. Future refinement of the device and technique in an animal model is necessary to lower the complication rate and increase patency rates.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)

UniBE Contributor:

Wanderer, Stefan; Casoni, Daniela; Remonda, Luca; Fandino, Javier and Marbacher, Serge

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0022-3085

Publisher:

American Association of Neurological Surgeons

Language:

English

Submitter:

Marla Rittiner

Date Deposited:

26 Jan 2021 17:01

Last Modified:

26 Jan 2021 17:01

Publisher DOI:

10.3171/2020.3.JNS20334

PubMed ID:

32502997

Uncontrolled Keywords:

CA = carotid artery CCA = common carotid artery DSA = digital subtraction angiography DWI = diffusion-weighted imaging ENO = endovascular assisted nonocclusive FA = femoral artery ICA = internal carotid artery MCA = middle cerebral artery New Zealand white rabbit PCA = posterior cerebral artery TOF-A = time-of-flight angiography bypass surgery cerebral bypass nonocclusive technique vascular disorders

BORIS DOI:

10.48350/150840

URI:

https://boris.unibe.ch/id/eprint/150840

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