Spiessberger, Alexander; Strange, Fabio; Gruter, Basil Erwin; Wanderer, Stefan; Casoni, Daniela; Gruber, Philipp; Diepers, Michael; Remonda, Luca; Fandino, Javier; Añon, Javier; Marbacher, Serge (2020). An endovascular assisted, nonocclusive cerebral bypass: a technical feasibility study in a rabbit model. Journal of neurosurgery, 134(6), pp. 1846-1851. American Association of Neurological Surgeons 10.3171/2020.3.JNS20334
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OBJECTIVE
Temporary parent vessel occlusion performed to establish a high-flow interpositional bypass carries the risk of infarcts. The authors investigated the feasibility of a novel technique to establish a high-flow bypass without temporary parent vessel occlusion in order to lower the risk of ischemic complications.
METHODS
In 10 New Zealand white rabbits, a carotid artery side-to-end anastomosis was performed under parent artery patency with a novel endovascular balloon device. Intraoperative angiography, postoperative neurological assessments, and postoperative MRI/MRA were performed to evaluate the feasibility and safety of the novel technique.
RESULTS
A patent anastomosis was established in 10 of 10 animals; 3 procedure-related complications occurred. No postoperative focal neurological deficits were observed. The MRI/MRA findings include no infarcts and bypass patency in 50% of the animals.
CONCLUSIONS
The authors demonstrated the feasibility of an endovascular assisted, nonocclusive high-flow bypass. Future refinement of the device and technique in an animal model is necessary to lower the complication rate and increase patency rates.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Neurochirurgie |
UniBE Contributor: |
Wanderer, Stefan, Casoni, Daniela, Remonda, Luca, Fandino, Javier, Marbacher, Serge |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0022-3085 |
Publisher: |
American Association of Neurological Surgeons |
Language: |
English |
Submitter: |
Marla Rittiner |
Date Deposited: |
26 Jan 2021 17:01 |
Last Modified: |
05 Dec 2022 15:44 |
Publisher DOI: |
10.3171/2020.3.JNS20334 |
PubMed ID: |
32502997 |
Uncontrolled Keywords: |
CA = carotid artery CCA = common carotid artery DSA = digital subtraction angiography DWI = diffusion-weighted imaging ENO = endovascular assisted nonocclusive FA = femoral artery ICA = internal carotid artery MCA = middle cerebral artery New Zealand white rabbit PCA = posterior cerebral artery TOF-A = time-of-flight angiography bypass surgery cerebral bypass nonocclusive technique vascular disorders |
BORIS DOI: |
10.48350/150840 |
URI: |
https://boris.unibe.ch/id/eprint/150840 |
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