Haghayegh Jahromi, Neda; Marchetti, Luca; Moalli, Federica; Duc, Donovan; Basso, Camilla; Tardent, Heidi; Kaba, Elisa; Deutsch, Urban; Pot, Caroline; Sallusto, Federica; Stein, Jens V.; Engelhardt, Britta (2020). Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis. Frontiers in immunology, 10(3056), p. 3056. Frontiers Research Foundation 10.3389/fimmu.2019.03056
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In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), myelin-specific T cells are activated in the periphery and differentiate in T helper (Th) 1 and Th17 effector cells, which cross the blood-brain barrier (BBB) to reach the central nervous system (CNS), where they induce neuroinflammation. Here, we explored the role of intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 in the activation of naïve myelin-specific T cells and in the subsequent migration of differentiated encephalitogenic Th1 and Th17 cells across the BBB in vitro and in vivo. While on antigen-presenting cells ICAM-1, but not ICAM-2 was required for the activation of naïve CD4+ T cells, endothelial ICAM-1 and ICAM-2 mediated both Th1 and Th17 cell migration across the BBB. ICAM-1/-2-deficient mice developed ameliorated typical and atypical EAE transferred by encephalitogenic Th1 and Th17 cells, respectively. Our study underscores important yet cell-specific contributions for ICAM-1 and ICAM-2 in EAE pathogenesis.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute 09 Interdisciplinary Units > Microscopy Imaging Center (MIC) |
UniBE Contributor: |
Haghayegh Jahromi, Neda, Marchetti, Luca, Moalli, Federica, Tardent, Heidi, Bouillet, Elisa Catherine, Deutsch, Urban, Stein, Jens Volker, Engelhardt, Britta |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1664-3224 |
Publisher: |
Frontiers Research Foundation |
Language: |
English |
Submitter: |
Ursula Zingg-Zünd |
Date Deposited: |
09 Feb 2021 17:20 |
Last Modified: |
02 Mar 2023 23:34 |
Publisher DOI: |
10.3389/fimmu.2019.03056 |
PubMed ID: |
31993059 |
Uncontrolled Keywords: |
ICAM-1 ICAM-2 T cell activation Th1 cells Th17 cells blood-brain barrier dendritic cells experimental autoimmune encephalomyelitis |
BORIS DOI: |
10.48350/150849 |
URI: |
https://boris.unibe.ch/id/eprint/150849 |
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