Immune cell trafficking across the blood-brain barrier in the absence and presence of neuroinflammation.

Marchetti, Luca; Engelhardt, Britta (2020). Immune cell trafficking across the blood-brain barrier in the absence and presence of neuroinflammation. Vascular biology (Bristol, England), 2(1), H1-H18. 10.1530/VB-19-0033

[img]
Preview
Text
PMID-32923970.pdf - Published Version
Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC).

Download (2MB) | Preview

To maintain the homeostatic environment required for proper function of CNS neurons the endothelial cells of CNS microvessels tightly regulate the movement of ions and molecules between the blood and the CNS. The unique properties of these blood vascular endothelial cells are termed blood-brain barrier (BBB) and extend to regulating immune cell trafficking into the immune privileged CNS during health and disease. In general, extravasation of circulating immune cells is a multi-step process regulated by the sequential interaction of adhesion and signalling molecules between the endothelial cells and the immune cells. Accounting for the unique barrier properties of CNS microvessels, immune cell migration across the BBB is distinct and characterized by several adaptations. Here we describe the mechanisms that regulate immune cell trafficking across the BBB during immune surveillance and neuroinflammation, with a focus on the current state-of-the-art in vitro and in vivo imaging observations.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Marchetti, Luca, Engelhardt, Britta

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2516-5658

Language:

English

Submitter:

Ursula Zingg-Zünd

Date Deposited:

27 Jan 2021 16:28

Last Modified:

05 Dec 2022 15:44

Publisher DOI:

10.1530/VB-19-0033

PubMed ID:

32923970

Uncontrolled Keywords:

blood-brain barrier immune cell migration life cell multiple sclerosis neuroinflammation

BORIS DOI:

10.48350/150852

URI:

https://boris.unibe.ch/id/eprint/150852

Actions (login required)

Edit item Edit item
Provide Feedback