Imaging technology of the lymphatic system.

Polomska, Anna K; Proulx, Steven T. (2021). Imaging technology of the lymphatic system. Advanced drug delivery reviews, 170, pp. 294-311. Elsevier 10.1016/j.addr.2020.08.013

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The lymphatic system plays critical roles in tissue fluid homeostasis and immunity and has been implicated in the development of many different pathologies, ranging from lymphedema, the spread of cancer to chronic inflammation. In this review, we first summarize the state-of-the-art of lymphatic imaging in the clinic and the advantages and disadvantages of these existing techniques. We then detail recent progress on imaging technology, including advancements in tracer design and injection methods, that have allowed visualization of lymphatic vessels with excellent spatial and temporal resolution in preclinical models. Finally, we describe the different approaches to quantifying lymphatic function that are being developed and discuss some emerging topics for lymphatic imaging in the clinic. Continued advancements in lymphatic imaging technology will be critical for the optimization of diagnostic methods for lymphatic disorders and the evaluation of novel therapies targeting the lymphatic system.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Proulx, Steven Thomas

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0169-409X

Publisher:

Elsevier

Language:

English

Submitter:

Ursula Zingg-Zünd

Date Deposited:

21 Jan 2021 13:39

Last Modified:

22 Mar 2021 01:33

Publisher DOI:

10.1016/j.addr.2020.08.013

PubMed ID:

32891679

Uncontrolled Keywords:

Contractility Lymph node Lymphangiography Lymphatic system Lymphatic vessel Lymphscintigraphy MRI NIR fluorescence Tracer

BORIS DOI:

10.48350/150922

URI:

https://boris.unibe.ch/id/eprint/150922

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