Fröhlich, Laura; Curthoys, Ian S.; Kösling, Sabrina; Obrist, Dominik; Rahne, Torsten; Plontke, Stefan K. (2020). Cervical and Ocular Vestibular-Evoked Myogenic Potentials in Patients With Intracochlear Schwannomas. Frontiers in neurology, 11, p. 549817. Frontiers Media S.A. 10.3389/fneur.2020.549817
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Objective: To evaluate ocular and cervical vestibular evoked myogenic potentials (oVEMPs and cVEMPs) in patients with solely intracochlear localization of an intralabyrinthine schwannoma (ILS).
Study Design: Retrospective analysis of a series of cases.
Setting: Monocentric study at a tertiary referral center.
Patients: Patients with intracochlear schwannoma (ICS) and VEMP measurements.
Outcome Measures: Signed asymmetry ratio (AR) of cVEMPs and oVEMPs to air conducted sound with AR cut-offs considered to be asymmetrical when exceeding ±30% for cVEMPs and ±40% for oVEMPs with respect to the side affected by the tumor (reduced amplitudes on the affected side indicated by negative values, enhanced amplitudes by positive values); VEMP amplitudes and latencies; tumor localization in the cochlear turn and scala.
Results: Nineteen patients with a solely intracochlear tumor (ICS patients) [10 males, 9 females, mean age 57.1 (SD: 13.4) years] were included in the study. On the affected side, cVEMPs were absent or reduced in 47% of the patients, normal in 32%, and enhanced in 21%. Ocular VEMPs on the affected side were absent or reduced in 53% of the patients, normal in 32% and enhanced in 15%. Latencies for cVEMPs and oVEMPs were not significantly different between the affected and non-affected side. In all patients with enhanced VEMPs, the tumor was located in the scala tympani and scala vestibuli.
Conclusions: As a new and unexpected finding, VEMP amplitudes can be enhanced in patients with intracochlear schwannoma, mimicking the third window syndrome.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Cardiovascular Engineering (CVE) |
UniBE Contributor: |
Obrist, Dominik |
ISSN: |
1664-2295 |
Publisher: |
Frontiers Media S.A. |
Language: |
English |
Submitter: |
Dominik Obrist |
Date Deposited: |
27 Jan 2021 13:49 |
Last Modified: |
05 Dec 2022 15:44 |
Publisher DOI: |
10.3389/fneur.2020.549817 |
PubMed ID: |
33192980 |
BORIS DOI: |
10.48350/150948 |
URI: |
https://boris.unibe.ch/id/eprint/150948 |
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