Influence of systematic variations of the stimulation profile on responses evoked with a vestibular implant prototype in humans

Crétallaz, Céline; Boutabla, Anissa; Cavuscens, Samuel; Ranieri, Maurizio; Nguyen, T A Khoa; Kingma, Herman; Van De Berg, Raymond; Guinand, Nils; Pérez Fornos, Angélica (2020). Influence of systematic variations of the stimulation profile on responses evoked with a vestibular implant prototype in humans. Journal of neural engineering, 17(3), 036027. IOP Publishing 10.1088/1741-2552/ab8342

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Objective: To explore the impact of different electrical stimulation profiles in human recipients of the Geneva-Maastricht vestibular implant prototypes.

Approach: Four implanted patients were recruited for this study. We investigated the relative efficacy of systematic variations of the electrical stimulus profile (phase duration, pulse rate, baseline level, modulation depth) in evoking vestibulo-ocular (eVOR) and perceptual responses.

Main results: Shorter phase durations and, to a lesser extent, slower pulse rates allowed maximizing the electrical dynamic range available for eliciting a wider range of intensities of vestibular percepts. When either the phase duration or the pulse rate was held constant, current modulation depth was the factor that had the most significant impact on peak velocity of the eVOR.

Significance: Our results identified important parametric variations that influence the measured responses. Furthermore, we observed that not all vestibular pathways seem equally sensitive to the electrical stimulus when the electrodes are placed in the semicircular canals and monopolar stimulation is used. This opens the door to evaluating new stimulation strategies for a vestibular implant, and suggests the possibility of selectively activating one vestibular pathway or the other in order to optimize rehabilitation outcomes.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Nguyen, Thuy Anh Khoa

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

1741-2552

Publisher:

IOP Publishing

Language:

English

Submitter:

Thuy Anh Khoa Nguyen

Date Deposited:

21 Jan 2021 16:02

Last Modified:

24 Jan 2021 03:00

Publisher DOI:

10.1088/1741-2552/ab8342

PubMed ID:

32213673

BORIS DOI:

10.48350/150980

URI:

https://boris.unibe.ch/id/eprint/150980

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