Effect of a plasmaelectrolytic coating on the strength retention of in vivo and in vitro degraded magnesium implants

Imwinkelried, T.; Beck, S.; Iizuka, Tateyuki; Schaller, Benoît (2013). Effect of a plasmaelectrolytic coating on the strength retention of in vivo and in vitro degraded magnesium implants. Acta biomaterialia, 9(10), pp. 8643-8649. Amsterdam: Elsevier 10.1016/j.actbio.2012.08.047

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The strength decrease in magnesium implants was studied in vitro and in vivo, with and without a protective plasmaelectrolytic coating. In vivo, degradation was examined by implanting rectangular plates on top of the nasal bone of miniature pigs. The presence of gas pockets in the soft tissue surrounding the implants was evaluated with intermediate X-rays and computed X-ray tomography scans before euthanasia. After 12 and 24weeks of in vivo degradation, the large rectangular plates were removed and mechanically tested in three-point bending. In vitro, identical plates were immersed in simulated body fluid for 4, 8 and 12weeks. In vitro and in vivo results showed that onset of gas release can be delayed by the plasmaelectrolytic coating. Mass loss and strength retention during in vivo degradation is about four times slower than during in vitro degradation for the chosen test conditions. Despite the slow degradation of the investigated WE43 alloy, the occurrence of gas pockets could not be completely avoided. Nevertheless, uniformity of degradation and reliable strength retention make this alloy a prime candidate for the use of magnesium in cranio-maxillofacial surgery.

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