Mocroft, Amanda; Lundgren, Jens D; Rockstroh, Juergen K; Aho, Inka; Wandeler, Gilles; Nielsen, Lars; Edwards, Simon; Viard, Jean-Paul; Lacombe, Karine; Fätkenheuer, Gerd; Guaraldi, Giovanni; Laguno, Montserrat; Llibre, Josep; Elinav, Hila; Flamholc, Leo; Gisinger, Martin; Paduta, Dzmitry; Khromova, Irina; Jilich, David; Rozplochowski, Blazej; ... (2020). Influence of Hepatitis C Coinfection and Treatment on Risk of Diabetes Mellitus in HIV-Positive Persons. Open Forum Infectious Diseases, 7(12), ofaa470. Oxford University Press 10.1093/ofid/ofaa470
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Background
The role of hepatitis C virus (HCV) coinfection and HCV-RNA in the development of diabetes mellitus (DM) in HIV-positive persons remains unclear.
Methods
Poisson regression was used to compare incidence rates of DM (blood glucose >11.1 mmol/L, HbA1C >6.5% or >48 mmol/mol, starting antidiabetic medicine or physician reported date of DM onset) between current HIV/HCV groups (anti-HCV-negative, spontaneously cleared HCV, chronic untreated HCV, successfully treated HCV, HCV-RNA-positive after HCV treatment).
Results
A total of 16 099 persons were included; at baseline 10 091 (62.7%) were HCV-Ab-negative, 722 (4.5%) were spontaneous clearers, 3614 (22.4%) were chronically infected, 912 (5.7%) had been successfully treated, and 760 (4.7%) were HCV-RNA-positive after treatment. During 136 084 person-years of follow-up (PYFU; median [interquartile range], 6.9 [3.6-13.2]), 1108 (6.9%) developed DM (crude incidence rate, 8.1/1000 PYFU; 95% CI, 7.7-8.6). After adjustment, there was no difference between the 5 HCV strata in incidence of DM (global P = .33). Hypertension (22.2%; 95% CI, 17.5%-26.2%) and body mass index >25 (22.0%; 95% CI, 10.4%-29.7%) had the largest population-attributable fractions for DM.
Conclusions
HCV coinfection and HCV cure were not associated with DM in this large study. The biggest modifiable risk factors were hypertension and obesity, and continued efforts to manage such comorbidities should be prioritized.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology |
UniBE Contributor: |
Wandeler, Gilles |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2328-8957 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Annelies Luginbühl |
Date Deposited: |
04 Feb 2021 15:11 |
Last Modified: |
05 Dec 2022 15:45 |
Publisher DOI: |
10.1093/ofid/ofaa470 |
PubMed ID: |
33409325 |
Uncontrolled Keywords: |
HIV diabetes mellitus direct-acting antivirals hepatitis C sustained virologic response |
BORIS DOI: |
10.48350/151163 |
URI: |
https://boris.unibe.ch/id/eprint/151163 |
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