Peri-implant soft tissue integration in humans - influence of materials: A study protocol for a randomised controlled trial and a pilot study results.

Borie, Manon; Lecloux, Geoffrey; Bosshardt, Dieter; Barrantes, Alejandro; Haugen, Håvard Jostein; Lambert, France; Bacevic, Miljana (2020). Peri-implant soft tissue integration in humans - influence of materials: A study protocol for a randomised controlled trial and a pilot study results. Contemporary clinical trials communications, 19, p. 100643. Elsevier 10.1016/j.conctc.2020.100643

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Background

Recently, there has been a growing interest in mucointegration as the formation of an early and long-standing soft tissue barrier seems essential for both the initial healing and long-term implant survival.

Aim

To develop an experimental method to characterize the mucointegration of different transgingival materials (titanium (Ti), polyetheretherketone (PEEK), polymethylmethacrylate (PMMA), zirconia (Zi), polymer infiltrated ceramic network (PICN), cobalt-chrome (Co-Cr), and lithium disilicate (LD)) in a human model.

Methods

The study is designed as a multi-part randomized controlled clinical trial. Ninety bone level Straumann implants will randomly receive an experimental, custom-made abutment to allow for the removal of the abutment together with the surrounding soft tissues using a punch biopsy device at 8 weeks of healing (10 per material). The specimens will be further processed for non-decalcified histology, followed by histomorphometric analysis. The same protocol will be used for additional 90 implants-abutments, but during harvesting, soft tissues will be separated from the abutment and processed for immunohistochemistry in order to study tissue inflammation and vascularization, while the abutments will undergo SEM analysis. Additionally, in vitro analyses, including SEM and profilometry, will be performed in order to characterize surface topography of all experimental materials.

Conclusion

The limited number of pilot samples presented herein indicate that the use of custom-made abutments in humans is a reproducible method to study peri-implant soft tissue integration. This further intensifies the rationale to compare different abutment materials, used as transgingival components in daily practice, under the same conditions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research

UniBE Contributor:

Bosshardt, Dieter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2451-8654

Publisher:

Elsevier

Language:

English

Submitter:

Doris Burri

Date Deposited:

14 Jan 2021 17:03

Last Modified:

12 Mar 2021 16:42

Publisher DOI:

10.1016/j.conctc.2020.100643

PubMed ID:

33083628

Uncontrolled Keywords:

PEEK PICN PMMA cobalt-chrome lithium disilicate mucointegration peri-implant tissue integration titanium zirconia

BORIS DOI:

10.48350/151273

URI:

https://boris.unibe.ch/id/eprint/151273

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