Investigation of selected respiratory effects of (dex)medetomidine in healthy Beagles

Pleyers, Tekla; Levionnois, Olivier; Siegenthaler, Joëlle; Spadavecchia, Claudia; Raillard, Mathieu (2020). Investigation of selected respiratory effects of (dex)medetomidine in healthy Beagles. Veterinary anaesthesia and analgesia, 47(5), pp. 667-671. Blackwell Science 10.1016/j.vaa.2020.05.001

[img] Text
1-s2.0-S146729872030091X-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (172kB) | Request a copy

Objective: To investigate the effects of sedative doses of intravenous (IV) medetomidine (MED) or dexmedetomidine (DEX) on selected respiratory variables in dogs.

Study design: Randomized, blinded, crossover study.

Animals: A total of eight healthy adult research Beagles.

Methods: Dogs breathing room air had an electrical impedance tomography belt placed around the chest and were maintained in right lateral recumbency. Respiratory rate (fR) in movements minute-1 (mpm) and changes in thoracic impedance (ΔZ) in arbitrary units (AU) were recorded for 120 seconds before (T0) and exactly 10 minutes (T10) after the administration of IV DEX (10 μg kg-1) or MED (20 μg kg-1), with a minimum washout period of 10 days between treatments. Minute ΔZ (ΔZ˙) was calculated by multiplying median ΔZ with fR. Data are presented as median (interquartile range). Significance for an overall effect of drugs (DEX versus MED) or treatment (T0 versus T10) was quantified with a two-way analysis of variance for repeated measures, followed by, when appropriate, Wilcoxon's signed rank test for each factor.

Results: Overall, fR decreased from 26 (22-29) mpm at T0 to 13 (10-21) mpm at T10 (p = 0.003) and ΔZ increased from 1.133 (0.856-1.599) AU at T0 to 1.650 (1.273-2.813) AU at T10 (p = 0.007), but ΔZ˙ did not change [30.375 (23.411-32.445) AU minute-1 at T0 and 30.581 (22.487-35.091) AU minute-1 at T10]. There was no difference between DEX and MED. Most dogs developed a peculiar breathing pattern characterized by clusters of breaths followed by short periods of apnoea.

Conclusions and clinical relevance: Both drugs caused a change in breathing pattern, reduction in fR and increase in ΔZ but did not affect ΔZ˙. It is likely that (dex)medetomidine resulted in reduction in fR and increase in tidal volume without impacting minute volume.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Anaesthesiology

UniBE Contributor:

Forss Pleyers, Tekla Ulrika; Levionnois, Olivier; Siegenthaler, Joëlle; Spadavecchia, Claudia and Raillard, Mathieu Clément

ISSN:

1467-2987

Publisher:

Blackwell Science

Language:

English

Submitter:

Claudia Spadavecchia

Date Deposited:

11 Feb 2021 10:02

Last Modified:

13 Feb 2021 07:39

Publisher DOI:

10.1016/j.vaa.2020.05.001

PubMed ID:

32792270

BORIS DOI:

10.48350/151756

URI:

https://boris.unibe.ch/id/eprint/151756

Actions (login required)

Edit item Edit item
Provide Feedback