Glutathione peroxidase overexpression causes aberrant ERK activation in neonatal mouse cortex after hypoxic preconditioning

Autheman, Delphine; Sheldon, R Ann; Chaudhuri, Nondini; von Arx, Sebastian; Siegenthaler, Corinne; Ferriero, Donna M; Christen, Stephan (2012). Glutathione peroxidase overexpression causes aberrant ERK activation in neonatal mouse cortex after hypoxic preconditioning. Pediatric research, 72(6), pp. 568-75. New York, N.Y.: Nature Publishing Group 10.1038/pr.2012.124

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Preconditioning of neonatal mice with nonlethal hypoxia (HPC) protects the brain from hypoxic-ischemic (HI) injury. Overexpression of human glutathione peroxidase 1 (GPx1), which normally protects the developing murine brain from HI injury, reverses HPC protection, suggesting that a certain threshold of hydrogen peroxide concentration is required for activation of HPC signaling.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Christen, Stephan

ISSN:

0031-3998

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:38

Last Modified:

05 Dec 2022 14:11

Publisher DOI:

10.1038/pr.2012.124

PubMed ID:

23007029

Web of Science ID:

000312518900003

URI:

https://boris.unibe.ch/id/eprint/15177 (FactScience: 222442)

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