Improved lipid target level attainment in patients with peripheral artery disease.

Dopheide, Jörn F.; Adam, Luise; Wiedmer, Sebastian; Kaspar, Mathias; Silbernagel, Günther; Baumgartner, Iris; Drexel, Heinz (2021). Improved lipid target level attainment in patients with peripheral artery disease. (In Press). Current vascular pharmacology 10.2174/1570161119666210111123621

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BACKGROUND

Patients with peripheral artery disease (PAD) fall under the category of a very high cardiovascular risk. Although, consequent lipid lowering therapy (LLT) is advised, only sparse data on attained target level in PAD exists.

OBJECTIVES

We aimed to analyse contemporary guideline recommendations for LLT in symptomatic PAD patients.

METHODS

monocentric, prospective, observational study involving 200 symptomatic PAD patients. Guideline target level attainment and LLT were analysed between 2017 and 2019.

RESULTS

Overall 78.5% of the patients were on statin therapy, mainly of high intensity with atorvastatin in 50% and rosuvastatin in 33% of the cases. Average statin dosage adjusted for simvastatin was 55 mg/d. Low density lipoproteincholesterol (LDL-C) was <1.8 mmol/L in 53% and <1.4 mmol/L in 34% of the cases. Mean LDL-C levels were at 1.85 ± 0.88 mmol/L. We observed no difference in the treatment and the target level attainment of patients with a stable PAD (intermittent claudication) or chronic critical PAD. However, patients with ≥1 vascular region affected (i.e. coronary and/or cerebrovascular) were treated more intensively and had lower LDL-C levels than patients with PAD alone.

CONCLUSION

It appears that there is more awareness and improvement of previously documented undertreatment of LDL-C levels in symptomatic PAD patients. Although statin treatment is initiated in the majority of patients, our findings call for a continuously intensified LLT in symptomatic PAD patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology

UniBE Contributor:

Dopheide, Jörn; Adam, Luise Leonore; Wiedmer, Sebastian; Kaspar, Mathias; Baumgartner, Iris and Drexel, Heinz

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 330 Economics

ISSN:

1875-6212

Language:

English

Submitter:

Catherine Gut

Date Deposited:

05 Feb 2021 16:13

Last Modified:

05 Feb 2021 16:13

Publisher DOI:

10.2174/1570161119666210111123621

PubMed ID:

33430734

Uncontrolled Keywords:

Low density lipoprotein-cholesterol Peripheral artery disease lipid lowering therapy statins target attainment.

URI:

https://boris.unibe.ch/id/eprint/151853

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