Characteristics of respiratory virus infections in autologous hematopoietic stem cell transplantation patients, a prospective study, Bern, Switzerland, 2015-2017.

Moret, Fabienne; Marschall, Jonas; Atkinson, Andrew; Farag, Sarah; Zimmerli, Stefan; Pabst, Thomas; Sommerstein, Rami (2021). Characteristics of respiratory virus infections in autologous hematopoietic stem cell transplantation patients, a prospective study, Bern, Switzerland, 2015-2017. Infectious diseases, 53(4), pp. 274-280. Taylor & Francis 10.1080/23744235.2021.1871642

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BACKGROUND

The epidemiology of respiratory virus infections (RVI) in patients undergoing autologous haematopoietic stem cell transplantation (auto-SCT) is not well described.

METHODS

Our goal was to describe the epidemiology of respiratory virus infections (RVI) in patients undergoing autologous haematopoietic stem cell transplantation (auto-SCT) in a single tertiary centre observation study during two respiratory virus seasons (2015-2017). All symptomatic auto-SCT patients were tested for RVI by nasopharyngeal swab.

RESULTS

156 transplantation episodes were included, 69% were male and, the median age was 57 years. We detected 19 RVIs in 156 transplantation episodes (12%). The median time to RVI after hospitalization was 13 days [IQR 7-13] and 15/19 (79%) had a possible nosocomial origin (occurrence ≥ 5 days after admission). The nosocomial infections included 5/15 (33%) 'severe' RVIs (3 influenza viruses, 1 parainfluenza virus, and 1 adenovirus) as well as 10/15 (66%) non-severe virus infections (including human rhinovirus and human coronavirus).

CONCLUSION

In approximately 10% of auto-SCT transplantation episodes, an RVI with likely nosocomial origin was detected and included 'severe viruses' such as influenza. Our study suggests that infection prevention measures in auto-SCT patients can be improved.

ABBREVIATIONS

AdV: adenovirus; ALL: acute lymphatic leukaemia; AML: acute myeloid leukaemia; auto-SCT: autologous haematopoietic stem cell transplantation; hCoV: human coronavirus; HD: Hodgkin's disease; hMPV: human metapneumovirus; HRV: human rhinovirus; HSCT: allogeneic haematopoietic stem cell transplantation; IQR: interquartile range; GCT: germ cell tumour; MM: multiple myeloma; NHL: non-Hodgkin lymphoma; PIV: parainfluenza virus; RSV: respiratory syncytial virus.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Marschall, Jonas; Atkinson, Andrew; Farag, Sarah Ahmed Ibrahim; Zimmerli, Stefan; Pabst, Thomas Niklaus and Sommerstein, Rami

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2374-4243

Publisher:

Taylor & Francis

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

15 Feb 2021 16:36

Last Modified:

18 Mar 2021 01:34

Publisher DOI:

10.1080/23744235.2021.1871642

PubMed ID:

33475447

Uncontrolled Keywords:

Respiratory virus infection autologous haematopoietic stem cell transplantation nosocomial infection

BORIS DOI:

10.48350/151868

URI:

https://boris.unibe.ch/id/eprint/151868

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