Natural Influenza Infection produces a greater Diversity of Humoral Responses than Vaccination in Immunosuppressed Transplant Recipients.

Hirzel, Cédric; Chruscinski, Andrzej; Ferreira, Victor H; L'Huillier, Arnaud G; Natori, Yochiro; Hoon Han, Sang; Cordero, Elisa; Humar, Atul; Kumar, Deepali (2021). Natural Influenza Infection produces a greater Diversity of Humoral Responses than Vaccination in Immunosuppressed Transplant Recipients. (In Press). American journal of transplantation Wiley-Blackwell 10.1111/ajt.16503

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The humoral immune response to influenza virus infection is complex and may be different compared to the antibody response elicited by vaccination. We analyzed the breadth of IgG and IgA responses in solid organ transplant recipients to a diverse collection of 86 influenza antigens elicited by natural influenza A virus (IAV) infection or by vaccination. Antibody levels were quantified using a custom antigen microarray. A total of 120 patients were included: 80 IAV infected (40 A/H1N1, 40 A/H3N2) and 40 vaccinated. Based on hierarchical clustering analysis, infection with either H1N1 or H3N2 virus showed a more diverse antibody response compared to vaccination. Similarly, H1N1 infected individuals showed a significant IgG response to 27.9% of array antigens, H3N2 infected patients to 43.0% of antigens, whereas vaccination elicited a less broad immune response (7.0% of antigens). Immune responses were not exclusively targeting influenza hemagglutinin proteins but were also directed against conserved influenza antigens. Serum IgA responses followed a similar profile. This study provides novel data on the breadth of antibody responses to influenza. We also found that the diversity of response is greater in influenza infected rather than vaccinated patients, providing a potential mechanistic rationale for suboptimal vaccine efficacy in this population.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Hirzel, Cédric

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1600-6135

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

15 Feb 2021 16:16

Last Modified:

15 Feb 2021 16:16

Publisher DOI:

10.1111/ajt.16503

PubMed ID:

33484237

BORIS DOI:

10.48350/151898

URI:

https://boris.unibe.ch/id/eprint/151898

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