Effects of Obesity and Thrombophilia on the Risk of Abortion in Women Undergoing In Vitro Fertilization.

Candeloro, Matteo; Di Nisio, Marcello; Ponzano, Adalisa; Tiboni, Gian Mario; Potere, Nicola; Tana, Marco; Rutjes, Anne W S; Porreca, Ettore (2020). Effects of Obesity and Thrombophilia on the Risk of Abortion in Women Undergoing In Vitro Fertilization. Frontiers in endocrinology, 11, p. 594867. Frontiers Research Foundation 10.3389/fendo.2020.594867

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Introduction

Obesity is associated with a higher risk of abortion in women undergoing in vitro fertilization (IVF). Whether thrombophilia amplifies this risk is currently unclear. The aim of this study was to evaluate the effects of thrombophilia on the risk of abortion in obese women treated with IVF.

Methods

Patient characteristics, presence of inherited or acquired thrombophilia, and comorbidities were prospectively collected before the procedure in consecutive women undergoing IVF. The primary outcome was the incidence of abortion among women who achieved a clinical pregnancy.

Results

A total of 633 non-obese and 49 obese Caucasian women undergoing IVF were included. 204 (32%) women achieved clinical pregnancy, of whom six had an ectopic pregnancy and 63 experienced an abortion. The incidence of abortion was higher in obese women compared to non-obese women after adjusting for age (64.3% vs. 29.3%, odds ratio [OR] 4.41; 95% CI 1.41 to 13.81). Women with one or more thrombophilia were at increased risk of abortion relative to those without thrombophilia (OR 2.70; 95% CI 1.34 to 5.45), and the risk seemed to be higher with hereditary (OR 5.12; 95% CI 1.77 to 14.8) than acquired thrombophilia (OR 1.92; 95% CI 0.52 to 5.12; p for interaction 0.194). Among obese women, the presence of one or more thrombophilia seemed associated with a substantially increased risk of abortion (unadjusted OR 14.00; 95% CI 0.94 to 207.6).

Conclusions

Obese women undergoing IVF have a high risk of abortion which seems further amplified by the concomitant presence of thrombophilia.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Rutjes, Anne

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1664-2392

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

05 Feb 2021 19:56

Last Modified:

13 Mar 2021 19:28

Publisher DOI:

10.3389/fendo.2020.594867

PubMed ID:

33424770

Uncontrolled Keywords:

abortion in vitro fertilization obesity pregnancy thrombophilia

BORIS DOI:

10.48350/151993

URI:

https://boris.unibe.ch/id/eprint/151993

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