Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection

Patin, Etienne; Kutalik, Zoltán; Guergnon, Julien; Bibert, Stéphanie; Nalpas, Bertrand; Jouanguy, Emmanuelle; Munteanu, Mona; Bousquet, Laurence; Argiro, Laurent; Halfon, Philippe; Boland, Anne; Müllhaupt, Beat; Semela, David; Dufour, Jean-François; Heim, Markus H; Moradpour, Darius; Cerny, Andreas; Malinverni, Raffaele; Hirsch, Hans; Martinetti, Gladys; ... (2012). Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection. Gastroenterology, 143(5), 1244-52.e1-12. Philadelphia, Pa.: Elsevier 10.1053/j.gastro.2012.07.097

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Polymorphisms in IL28B were shown to affect clearance of hepatitis C virus (HCV) infection in genome-wide association (GWA) studies. Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We performed a 2-stage GWA study of liver fibrosis progression related to HCV infection.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Dufour, Jean-François

ISSN:

0016-5085

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:38

Last Modified:

17 Mar 2015 21:30

Publisher DOI:

10.1053/j.gastro.2012.07.097

PubMed ID:

22841784

Web of Science ID:

000310459700037

URI:

https://boris.unibe.ch/id/eprint/15204 (FactScience: 222496)

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