Classical swine fever virus: the past, present and future.

Ganges, Llilianne; Crooke, Helen R; Bohórquez, Jose Alejandro; Postel, Alexander; Sakoda, Yoshihiro; Becher, Paul; Ruggli, Nicolas (2020). Classical swine fever virus: the past, present and future. Virus research, 289, p. 198151. Elsevier 10.1016/j.virusres.2020.198151

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Classical swine fever (CSF) is among the most relevant viral epizootic diseases of swine. Due to its severe economic impact, CSF is notifiable to the world organisation for animal health. Strict control policies, including systematic stamping out of infected herds with and without vaccination, have permitted regional virus eradication. Nevertheless, CSF virus (CSFV) persists in certain areas of the world and has re-emerged regularly. This review summarizes the basic established knowledge in the field and provides a comprehensive and updated overview of the recent advances in fundamental CSFV research, diagnostics and vaccine development. It covers the latest discoveries on the genetic diversity of pestiviruses, with implications for taxonomy, the progress in understanding disease pathogenesis, immunity against acute and persistent infections, and the recent findings in virus-host interactions and virulence determinants. We also review the progress and pitfalls in the improvement of diagnostic tools and the challenges in the development of modern and efficacious marker vaccines compatible with serological tests for disease surveillance. Finally, we highlight the gaps that require research efforts in the future.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Ruggli, Nicolas

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture

ISSN:

0168-1702

Publisher:

Elsevier

Language:

English

Submitter:

Achim Braun Parham

Date Deposited:

08 Apr 2021 11:15

Last Modified:

11 Apr 2021 03:05

Publisher DOI:

10.1016/j.virusres.2020.198151

PubMed ID:

32898613

Uncontrolled Keywords:

CSF CSFV Diagnostic tools Disease control Disease pathogenesis Immunity Taxonomy Vaccine development Virulence determinants

BORIS DOI:

10.7892/boris.152070

URI:

https://boris.unibe.ch/id/eprint/152070

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