Contagious Bovine and Caprine Pleuropneumonia: a research community's recommendations for the development of better vaccines.

Jores, Joerg; Baldwin, Cynthia; Blanchard, Alain; Browning, Glenn F; Colston, Angie; Gerdts, Volker; Goovaerts, Danny; Heller, Martin; Juleff, Nick; Labroussaa, Fabien; Liljander, Anne; Muuka, Geoffrey; Nene, Vish; Nir-Paz, Ran; Sacchini, Flavio; Summerfield, Artur; Thiaucourt, François; Unger, Hermann; Vashee, Sanjay; Wang, Xiumei; ... (2020). Contagious Bovine and Caprine Pleuropneumonia: a research community's recommendations for the development of better vaccines. npj vaccines, 5(1), p. 66. Nature Publishing Group 10.1038/s41541-020-00214-2

Preview

Text b152074.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview

Contagious bovine pleuropneumonia (CBPP) and contagious caprine pleuropneumonia (CCPP) are major infectious diseases of ruminants caused by mycoplasmas in Africa and Asia. In contrast with the limited pathology in the respiratory tract of humans infected with mycoplasmas, CBPP and CCPP are devastating diseases associated with high morbidity and mortality. Beyond their obvious impact on animal health, CBPP and CCPP negatively impact the livelihood and wellbeing of a substantial proportion of livestock-dependent people affecting their culture, economy, trade and nutrition. The causative agents of CBPP and CCPP are Mycoplasma mycoides subspecies mycoides and Mycoplasma capricolum subspecies capripneumoniae, respectively, which have been eradicated in most of the developed world. The current vaccines used for disease control consist of a live attenuated CBPP vaccine and a bacterin vaccine for CCPP, which were developed in the 1960s and 1980s, respectively. Both of these vaccines have many limitations, so better vaccines are urgently needed to improve disease control. In this article the research community prioritized biomedical research needs related to challenge models, rational vaccine design and protective immune responses. Therefore, we scrutinized the current vaccines as well as the challenge-, pathogenicity- and immunity models. We highlight research gaps and provide recommendations towards developing safer and more efficacious vaccines against CBPP and CCPP.

Interest & Impact

Downloads

52 since deposited on 08 Apr 2021
25 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item