SARS-CoV-2 Inhibition by Sulfonated Compounds.

Gasbarri, Matteo; V'kovski, Philip; Torriani, Giulia; Thiel, Volker; Stellacci, Francesco; Tapparel, Caroline; Cagno, Valeria (2020). SARS-CoV-2 Inhibition by Sulfonated Compounds. Microorganisms, 8(12) MDPI 10.3390/microorganisms8121894

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Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) depends on angiotensin converting enzyme 2 (ACE2) for cellular entry, but it might also rely on attachment receptors such as heparan sulfates. Several groups have recently demonstrated an affinity of the SARS-CoV2 spike protein for heparan sulfates and a reduced binding to cells in the presence of heparin or heparinase treatment. Here, we investigated the inhibitory activity of several sulfated and sulfonated molecules, which prevent interaction with heparan sulfates, against vesicular stomatitis virus (VSV)-pseudotyped-SARS-CoV-2 and the authentic SARS-CoV-2. Sulfonated cyclodextrins and nanoparticles that have recently shown broad-spectrum non-toxic virucidal activity against many heparan sulfates binding viruses showed inhibitory activity in the micromolar and nanomolar ranges, respectively. In stark contrast with the mechanisms that these compounds present for these other viruses, the inhibition against SARS-CoV-2 was found to be simply reversible.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology

UniBE Contributor:

V'kovski, Philip and Thiel, Volker Earl

Subjects:

600 Technology > 630 Agriculture

ISSN:

2076-2607

Publisher:

MDPI

Language:

English

Submitter:

Achim Braun Parham

Date Deposited:

11 Mar 2021 14:15

Last Modified:

11 Mar 2021 14:15

Publisher DOI:

10.3390/microorganisms8121894

PubMed ID:

33265927

Uncontrolled Keywords:

SARS-CoV-2 antiviral attachment inhibitor heparan sulfates

BORIS DOI:

10.48350/152077

URI:

https://boris.unibe.ch/id/eprint/152077

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