Immunodeficiency and Cancer in 3.5 Million People Living with Human Immunodeficiency Virus: the South African HIV Cancer Match Study.

Ruffieux, Yann; Muchengeti, Mazvita; Egger, Matthias; Efthimiou, Orestis; Bartels, Lina; Olago, Victor; Davidović, Maša; Dhokotera, Tafadzwa; Bohlius, Julia; Singh, Elvira; Rohner, Eliane (2021). Immunodeficiency and Cancer in 3.5 Million People Living with Human Immunodeficiency Virus: the South African HIV Cancer Match Study. (In Press). Clinical infectious diseases Oxford University Press 10.1093/cid/ciab087

[img] Text
Ruffieux_ClinInfectDis_2021_AAM.pdf - Accepted Version
Restricted to registered users only until 3 February 2022.
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy
[img] Text
Ruffieux_ClinInfectDis_2021_epub.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (479kB) | Request a copy

BACKGROUND

We analysed associations between immunodeficiency and cancer incidence in a nationwide cohort of people living with the human immunodeficiency virus (HIV) in South Africa.

METHODS

We used data from the South African HIV Cancer Match study built on HIV-related laboratory measurements from the National Health Laboratory Services and cancer records from the National Cancer Registry. We evaluated associations between time-updated CD4 cell count and cancer incidence rates using Cox proportional hazards models. We reported adjusted hazard ratios (aHR) over a grid of CD4 values and estimated the aHR per 100 CD4 cells/µl decrease.

RESULTS

Of 3,532,266 people living with HIV (PLWH), 15,078 developed cancer. The most common cancers were cervical cancer (4,150 cases), Kaposi sarcoma (2,262 cases), and non-Hodgkin lymphoma (1,060 cases). The association between lower CD4 cell count and higher cancer incidence rates was strongest for conjunctival cancer (aHR per 100 CD4 cells/µl decrease: 1.46, 95% confidence interval [CI] 1.38-1.54), Kaposi sarcoma (aHR 1.23, 95% CI 1.20-1.26), and non-Hodgkin lymphoma (aHR 1.18, 95% CI 1.14-1.22). Among infection-unrelated cancers, lower CD4 cell counts were associated with higher incidence rates of oesophageal cancer (aHR 1.06, 95 CI 1.00-1.11), but not breast, lung, or prostate cancer.

CONCLUSIONS

Lower CD4 cell counts were associated with an increased risk of developing various infection-related cancers among PLWH. Reducing HIV-induced immunodeficiency may be a potent cancer prevention strategy among PLWH in sub-Saharan Africa, a region heavily burdened by cancers attributable to infections.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)
Graduate School for Health Sciences (GHS)

UniBE Contributor:

Ruffieux, Yann; Egger, Matthias; Efthimiou, Orestis; Bartels, Lina; Davidović, Maša; Dhokotera, Tafadzwa Gladys; Bohlius, Julia Friederike and Rohner, Eliane

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1537-6591

Publisher:

Oxford University Press

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

09 Feb 2021 18:05

Last Modified:

06 Apr 2021 17:32

Publisher DOI:

10.1093/cid/ciab087

PubMed ID:

33530095

Uncontrolled Keywords:

CD4 cell count HIV South Africa cancer immunodeficiency

BORIS DOI:

10.48350/152087

URI:

https://boris.unibe.ch/id/eprint/152087

Actions (login required)

Edit item Edit item
Provide Feedback