Repeat-dose sirolimus pharmacokinetics and pharmacodynamics in patients with hepatic allografts

Reichen, Jürg; Stickel, Felix; Bhattacharya, Indranil; Matschke, Kyle; Maller, Eric; Korth-Bradley, Joan (2012). Repeat-dose sirolimus pharmacokinetics and pharmacodynamics in patients with hepatic allografts. European journal of clinical pharmacology, 68(5), pp. 589-97. Berlin: Springer 10.1007/s00228-011-1172-7

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To determine sirolimus steady-state pharmacokinetics, and to assess the relationship between time-normalized trough sirolimus concentration (C(min,TN)) and evidence of efficacy (rejection and death) and adverse reactions (stomatitis and pneumonia) in liver allograft patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Stickel, Felix

ISSN:

0031-6970

Publisher:

Springer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:38

Last Modified:

17 Mar 2015 21:30

Publisher DOI:

10.1007/s00228-011-1172-7

PubMed ID:

22143911

Web of Science ID:

000303452800015

URI:

https://boris.unibe.ch/id/eprint/15218 (FactScience: 222510)

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