Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells.

Duhan, Vikas; Khairnar, Vishal; Kitanovski, Simo; Hamdan, Thamer A; Klein, Andrés D; Lang, Judith; Ali, Murtaza; Adomati, Tom; Bhat, Hilal; Friedrich, Sarah-Kim; Li, Fanghui; Krebs, Philippe; Futerman, Anthony H; Addo, Marylyn M; Hardt, Cornelia; Hoffmann, Daniel; Lang, Philipp A; Lang, Karl S (2021). Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells. Frontiers in immunology, 11, p. 607889. Frontiers Research Foundation 10.3389/fimmu.2020.607889

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Early and strong production of IFN-I by dendritic cells is important to control vesicular stomatitis virus (VSV), however mechanisms which explain this cell-type specific innate immune activation remain to be defined. Here, using a genome wide association study (GWAS), we identified Integrin alpha-E (Itgae, CD103) as a new regulator of antiviral IFN-I production in a mouse model of vesicular stomatitis virus (VSV) infection. CD103 was specifically expressed by splenic conventional dendritic cells (cDCs) and limited IFN-I production in these cells during VSV infection. Mechanistically, CD103 suppressed AKT phosphorylation and mTOR activation in DCs. Deficiency in CD103 accelerated early IFN-I in cDCs and prevented death in VSV infected animals. In conclusion, CD103 participates in regulation of cDC specific IFN-I induction and thereby influences immune activation after VSV infection.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology

UniBE Contributor:

Krebs, Philippe

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

1664-3224

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Philippe Krebs

Date Deposited:

17 Feb 2021 09:23

Last Modified:

13 Mar 2021 17:29

Publisher DOI:

10.3389/fimmu.2020.607889

PubMed ID:

33584680

Uncontrolled Keywords:

AKT CD103 GWAS IFN-I Itgae genome wide association screen mTOR vesicular stomatitis virus

BORIS DOI:

10.48350/152257

URI:

https://boris.unibe.ch/id/eprint/152257

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