Understanding 'Non-genetic' Inheritance: Insights from Molecular-Evolutionary Crosstalk.

Adrian-Kalchhauser, Irene; Sultan, Sonia E; Shama, Lisa N S; Spence-Jones, Helen; Tiso, Stefano; Keller Valsecchi, Claudia Isabelle; Weissing, Franz J (2020). Understanding 'Non-genetic' Inheritance: Insights from Molecular-Evolutionary Crosstalk. Trends in ecology & evolution, 35(12), pp. 1078-1089. Elsevier Current Trends 10.1016/j.tree.2020.08.011

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Understanding the evolutionary and ecological roles of 'non-genetic' inheritance (NGI) is daunting due to the complexity and diversity of epigenetic mechanisms. We draw on insights from molecular and evolutionary biology perspectives to identify three general features of 'non-genetic' inheritance systems: (i) they are functionally interdependent with, rather than separate from, DNA sequence; (ii) precise mechanisms vary phylogenetically and operationally; and (iii) epigenetic elements are probabilistic, interactive regulatory factors and not deterministic 'epialleles' with defined genomic locations and effects. We discuss each of these features and offer recommendations for future empirical and theoretical research that implements a unifying inherited gene regulation (IGR) approach to studies of 'non-genetic' inheritance.

Item Type:

Journal Article (Review Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Center for Fish and Wildlife Health (FIWI)

UniBE Contributor:

Adrian-Kalchhauser, Irene

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 630 Agriculture

ISSN:

0169-5347

Publisher:

Elsevier Current Trends

Language:

English

Submitter:

Achim Braun Parham

Date Deposited:

17 Feb 2021 14:29

Last Modified:

13 Mar 2021 15:57

Publisher DOI:

10.1016/j.tree.2020.08.011

PubMed ID:

33036806

Uncontrolled Keywords:

epiallelic variation epigenetics extended inheritance inherited gene regulation theoretical models transgenerational effects

BORIS DOI:

10.48350/152276

URI:

https://boris.unibe.ch/id/eprint/152276

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