True-severe Stenosis 1 in Paradoxical Low-flow Low-gradient Aortic Stenosis: Outcomes after Transcatheter Aortic Valve Replacement.

Okuno, Taishi; Corpataux, Noé; Spano, Giancarlo; Gräni, Christoph; Heg, Dik; Brugger, Nicolas; Lanz, Jonas; Praz, Fabien; Stortecky, Stefan; Siontis, George C M; Windecker, Stephan; Pilgrim, Thomas (2021). True-severe Stenosis 1 in Paradoxical Low-flow Low-gradient Aortic Stenosis: Outcomes after Transcatheter Aortic Valve Replacement. European heart journal. Quality of care & clinical outcomes, 7(4), pp. 366-377. Oxford University Press 10.1093/ehjqcco/qcab010

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The ESC/EACTS guidelines propose criteria that determine the likelihood of true-severe aortic stenosis (AS). We aimed to investigate the impact of the guideline-based criteria of the likelihood of true-severe AS in patients with low-flow low-gradient (LFLG) AS with preserved ejection fraction (pEF) on outcomes following transcatheter aortic valve replacement (TAVR).


In a prospective TAVR registry, LFLG-AS patients with pEF were retrospectively categorized into high (criteria ≥6) and intermediate (criteria <6) likelihood of true-severe AS. Hemodynamic, functional and clinical outcomes were compared with high-gradient AS patients with pEF. Among 632 eligible patients, 202 fulfilled diagnostic criteria for LFLG-AS. Significant hemodynamic improvement after TAVR was observed in LFLG-AS patients, irrespective of the likelihood. Although >70% of LFLG-AS patients had functional improvement, impaired functional status (NYHA III/IV) persisted more frequently at 1 year in LFLG-AS than in high-gradient AS patients (7.8%), irrespective of the likelihood (high: 17.4%, p = 0.006; intermediate: 21.1%, p < 0.001). All-cause death at 1 year occurred in 6.6% of high-gradient AS patients, 10.9% of LFLG-AS patients with high likelihood (HRadj 1.43, 95%CI 0.68-3.02), and in 7.2% of those with intermediate likelihood (HRadj 0.92, 95%CI 0.39-2.18). Among the criteria, only the absence of AVA ≤0.8 cm2 emerged as an independent predictor of treatment futility, a combined endpoint of all-cause death or NYHA III/IV at 1 year (OR 2.70, 95%CI 1.14-6.25).


Patients with LFLG-AS with pEF had comparable survival but worse functional status at 1 year than high-gradient AS with pEF, irrespective of the likelihood of true-severe AS.


Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern

UniBE Contributor:

Okuno, Taishi; Spano, Giancarlo; Gräni, Christoph; Heg, Dierik Hans; Brugger, Nicolas Jacques; Lanz, Jonas; Praz, Fabien Daniel; Stortecky, Stefan; Siontis, Georgios; Windecker, Stephan and Pilgrim, Thomas


600 Technology > 610 Medicine & health




Oxford University Press




Doris Kopp Heim

Date Deposited:

16 Feb 2021 19:48

Last Modified:

14 Jan 2022 07:24

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

aortic stenosis low-flow low-gradient aortic stenosis preserved ejection fraction transcatheter aortic valve implantation transcatheter aortic valve replacement



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