Model‐based genotype and ancestry estimation for potential hybrids with mixed‐ploidy

Shastry, Vivaswat; Adams, Paula E.; Lindtke, Dorothea; Mandeville, Elizabeth G.; Parchman, Thomas L.; Gompert, Zachariah; Buerkle, C. Alex (2021). Model‐based genotype and ancestry estimation for potential hybrids with mixed‐ploidy (In Press). Molecular ecology resources Wiley 10.1111/1755-0998.13330

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Non‐random mating among individuals can lead to spatial clustering of genetically similar individuals and population stratification. This deviation from panmixia is commonly observed in natural populations. Consequently, individuals can have parentage in single populations or involving hybridization between differentiated populations. Accounting for this mixture and structure is important when mapping the genetics of traits and learning about the formative evolutionary processes that shape genetic variation among individuals and populations. Stratified genetic relatedness among individuals is commonly quantified using estimates of ancestry that are derived from a statistical model. Development of these models for polyploid and mixed‐ploidy individuals and populations has lagged behind those for diploids. Here, we extend and test a hierarchical Bayesian model, called entropy, which can use low‐depth sequence data to estimate genotype and ancestry parameters in autopolyploid and mixed‐ploidy individuals (including sex chromosomes and autosomes within individuals). Our analysis of simulated data illustrated the trade‐off between sequencing depth and genome coverage and found lower error associated with low‐depth sequencing across a larger fraction of the genome than with high‐depth sequencing across a smaller fraction of the genome. The model has high accuracy and sensitivity as verified with simulated data and through analysis of admixture among populations of diploid and tetraploid Arabidopsis arenosa.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Plant Sciences (IPS) > Plant Development
08 Faculty of Science > Department of Biology > Institute of Plant Sciences (IPS)

UniBE Contributor:

Lindtke, Dorothea

Subjects:

500 Science > 580 Plants (Botany)

ISSN:

1755-098X

Publisher:

Wiley

Language:

English

Submitter:

Peter Alfred von Ballmoos-Haas

Date Deposited:

01 Mar 2021 15:37

Last Modified:

01 Mar 2021 15:37

Publisher DOI:

10.1111/1755-0998.13330

Uncontrolled Keywords:

admixture, ancestry, genotype likelihoods, hybridization, introgression, polyploids

BORIS DOI:

10.48350/152722

URI:

https://boris.unibe.ch/id/eprint/152722

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