The SilenT AtRial FIBrillation (STAR-FIB) study programme - design and rationale.

Nozica, Nikolas; Lam, Anna; Goulouti, Eleni; Elchinova, Elena Georgieva; Spirito, Alessandro; Branca, Mattia; Servatius, Helge; Noti, Fabian; Seiler, Jens; Baldinger, Samuel H.; Haeberlin, Andreas; De Marchi, Stefano F.; Asatryan, Babken; Rodondi, Nicolas; Donzé, Jacques; Aujesky, Drahomir; Tanner, Hildegard; Reichlin, Tobias; Jüni, Peter and Roten, Laurent (2021). The SilenT AtRial FIBrillation (STAR-FIB) study programme - design and rationale. Swiss medical weekly, 151, w20421. EMH Schweizerischer Ärzteverlag 10.4414/smw.2021.20421

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AIMS OF THE STUDY

Anticoagulation of patients with screen-detected atrial fibrillation may prevent ischaemic strokes. The STAR-FIB study programme aims to determine the age- and sex-specific prevalence of silent atrial fibrillation and to develop a clinical prediction model to identify patients at risk of undiagnosed atrial fibrillation in a hospitalised patient population.

METHODS

The STAR-FIB study programme includes a prospective cohort study and a case-control study of hospitalised patients aged 65–84 years, evenly distributed for both age and sex. We recruited 795 patients without atrial fibrillation for the cohort study (49.2% females; median age 74.8 years). All patients had three serial 7-day Holter ECGs to screen for silent atrial fibrillation. The primary endpoint will be any episode of atrial fibrillation or atrial flutter of ≥30 seconds duration. The age- and sex-specific prevalence of newly diagnosed atrial fibrillation will be estimated. For the case-control study, 120 patients with paroxysmal atrial fibrillation were recruited as cases (41.7% females; median age 74.6 years); controls will be randomly selected from the cohort study in a 2:1 ratio. All participants in the cohort study and all cases were prospectively evaluated including clinical, laboratory, echocardiographic and electrical parameters. A clinical prediction model for undiagnosed atrial fibrillation will be derived in the case-control study and externally validated in the cohort study.

CONCLUSIONS

The STAR-FIB study programme will estimate the age- and sex-specific prevalence of silent atrial fibrillation in a hospitalised patient population, and develop and validate a clinical prediction model to identify patients at risk of silent atrial fibrillation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM)
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine

UniBE Contributor:

Nozica, Nikolas; Lam, Anna; Goulouti, Eleni; Elchinova, Elena Georgieva; Spirito, Alessandro; Branca, Mattia; Servatius, Helge Simon; Noti, Fabian; Seiler, Jens; Baldinger, Samuel Hannes; Häberlin, Andreas David Heinrich; De Marchi, Stefano; Asatryan, Babken; Rodondi, Nicolas; Aujesky, Drahomir; Tanner, Hildegard; Reichlin, Tobias Roman and Roten, Laurent

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1424-7860

Publisher:

EMH Schweizerischer Ärzteverlag

Funders:

[4] Swiss National Science Foundation ; [116] Swiss Heart Foundation = Schweizerische Herzstiftung

Language:

English

Submitter:

Christine Baumgartner

Date Deposited:

15 Mar 2021 11:08

Last Modified:

15 Mar 2021 11:08

Publisher DOI:

10.4414/smw.2021.20421

PubMed ID:

33641108

BORIS DOI:

10.48350/152796

URI:

https://boris.unibe.ch/id/eprint/152796

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