Degen, Martin; Scherberich, Arnaud; Tucker, Richard P (2021). Tenascin-W: Discovery, Evolution, and Future Prospects. Frontiers in immunology, 11(623305), p. 623305. Frontiers Research Foundation 10.3389/fimmu.2020.623305
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Of the four tenascins found in bony fish and tetrapods, tenascin-W is the least understood. It was first discovered in the zebrafish and later in mouse, where it was mistakenly named tenascin-N. Tenascin-W is expressed primarily in developing and mature bone, in a subset of stem cell niches, and in the stroma of many solid tumors. Phylogenetic studies show that it is the most recent tenascin to evolve, appearing first in bony fishes. Its expression in bone and the timing of its evolutionary appearance should direct future studies to its role in bone formation, in stem cell niches, and in the treatment and detection of cancer.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Orthodontic Research |
UniBE Contributor: |
Degen, Martin |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1664-3224 |
Publisher: |
Frontiers Research Foundation |
Language: |
English |
Submitter: |
Renate Imhof-Etter |
Date Deposited: |
17 Mar 2021 17:57 |
Last Modified: |
05 Dec 2022 15:48 |
Publisher DOI: |
10.3389/fimmu.2020.623305 |
PubMed ID: |
33603752 |
Uncontrolled Keywords: |
cell adhesion cell differentiation cell migration extracellular matrix phylogeny |
BORIS DOI: |
10.48350/152944 |
URI: |
https://boris.unibe.ch/id/eprint/152944 |
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