Tenascin-W: Discovery, Evolution, and Future Prospects.

Degen, Martin; Scherberich, Arnaud; Tucker, Richard P (2021). Tenascin-W: Discovery, Evolution, and Future Prospects. Frontiers in immunology, 11(623305), p. 623305. Frontiers Research Foundation 10.3389/fimmu.2020.623305

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Of the four tenascins found in bony fish and tetrapods, tenascin-W is the least understood. It was first discovered in the zebrafish and later in mouse, where it was mistakenly named tenascin-N. Tenascin-W is expressed primarily in developing and mature bone, in a subset of stem cell niches, and in the stroma of many solid tumors. Phylogenetic studies show that it is the most recent tenascin to evolve, appearing first in bony fishes. Its expression in bone and the timing of its evolutionary appearance should direct future studies to its role in bone formation, in stem cell niches, and in the treatment and detection of cancer.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Orthodontic Research

UniBE Contributor:

Degen, Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1664-3224

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Renate Imhof-Etter

Date Deposited:

17 Mar 2021 17:57

Last Modified:

05 Dec 2022 15:48

Publisher DOI:

10.3389/fimmu.2020.623305

PubMed ID:

33603752

Uncontrolled Keywords:

cell adhesion cell differentiation cell migration extracellular matrix phylogeny

BORIS DOI:

10.48350/152944

URI:

https://boris.unibe.ch/id/eprint/152944

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