Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis

Ming, Xiu-Fen; Rajapakse, Angana G; Yepuri, Gautham; Xiong, Yuyan; Carvas, João M; Ruffieux, Jean; Scerri, Isabelle; Wu, Zongsong; Popp, Katja; Li, Jianhui; Sartori, Claudio; Scherrer, Urs; Kwak, Brenda R; Montani, Jean-Pierre; Yang, Zhihong (2012). Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis. Journal of the American Heart Association, 1(4), e000992. New York, N.Y.: American Heart Association

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Macrophage-mediated chronic inflammation is mechanistically linked to insulin resistance and atherosclerosis. Although arginase I is considered antiinflammatory, the role of arginase II (Arg-II) in macrophage function remains elusive. This study characterizes the role of Arg-II in macrophage inflammatory responses and its impact on obesity-linked type II diabetes mellitus and atherosclerosis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Scherrer, Urs

ISSN:

2047-9980

Publisher:

American Heart Association

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:38

Last Modified:

17 Mar 2015 21:30

PubMed ID:

23130157

URI:

https://boris.unibe.ch/id/eprint/15297 (FactScience: 222606)

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