First experience of SARS-CoV-2 infections in solid organ transplant recipients in the Swiss Transplant Cohort Study.

Tschopp, Jonathan; L'Huillier, Arnaud G; Mombelli, Matteo; Mueller, Nicolas J; Khanna, Nina; Garzoni, Christian; Meloni, Dario; Papadimitriou-Olivgeris, Matthaios; Neofytos, Dionysios; Hirsch, Hans H; Schuurmans, Macé M; Müller, Thomas; Berney, Thierry; Steiger, Jürg; Pascual, Manuel; Manuel, Oriol; van Delden, Christian (2020). First experience of SARS-CoV-2 infections in solid organ transplant recipients in the Swiss Transplant Cohort Study. American journal of transplantation, 20(10), pp. 2876-2882. Wiley-Blackwell 10.1111/ajt.16062

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Immunocompromised patients may be at increased risk for complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, comprehensive data of SARS-CoV-2 infection in solid organ transplant (SOT) recipients are still lacking. We performed a multicenter nationwide observational study within the Swiss Transplant Cohort Study (STCS) to describe the epidemiology, clinical presentation, treatment and outcomes of the first microbiologically documented SARS-CoV-2 infection among SOT recipients. Overall, 21 patients were included with a median age of 56 years (10 kidney, 5 liver, 1 pancreas, 1 lung, 1 heart and 3 combined transplantations). The most common presenting symptoms were fever (76%), dry cough (57%), nausea (33%), and diarrhea (33%). Ninety-five percent and 24% of patients required hospital and ICU admission, respectively, and 19% were intubated. After a median of 33 days of follow-up, 16 patients were discharged, 3 were still hospitalized and 2 patients died. These data suggest that clinical manifestations of SARS-CoV-2 infection in middle-aged SOT recipients appear to be similar to the general population without an apparent higher rate of complications. These results need to be confirmed in larger cohorts.

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