Koenig, Thomas; van Swam, Claudia; Dierks, Thomas; Hubl, Daniela (2012). Is gamma band EEG synchronization reduced during auditory driving in schizophrenia patients with auditory verbal hallucinations? Schizophrenia Research, 141(2-3), pp. 266-70. Elsevier 10.1016/j.schres.2012.07.016
![[img]](https://boris.unibe.ch/style/images/fileicons/text.png) |
Text
1-s2.0-S0920996412004100-main.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (331kB) |
Auditory verbal hallucinations (AVH) in schizophrenia patients assumingly result from a state inadequate activation of the primary auditory system. We tested brain responsiveness to auditory stimulation in healthy controls (n=26), and in schizophrenia patients that frequently (n=18) or never (n=11) experienced AVH. Responsiveness was assessed by driving the EEG with click-tones at 20, 30 and 40Hz. We compared stimulus induced EEG changes between groups using spectral amplitude maps and a global measure of phase-locking (GFS). As expected, the 40Hz stimulation elicited the strongest changes. However, while controls and non-hallucinators increased 40Hz EEG activity during stimulation, a left-lateralized decrease was observed in the hallucinators. These differences were significant (p=.02). As expected, GFS increased during stimulation in controls (p=.08) and non-hallucinating patients (p=.06), which was significant when combining the two groups (p=.01). In contrast, GFS decreased with stimulation in hallucinating patients (p=0.13), resulting in a significantly different GFS response when comparing subjects with and without AVH (p<.01). Our data suggests that normally, 40Hz stimulation leads to the activation of a synchronized network representing the sensory input, but in hallucinating patients, the same stimulation partly disrupts ongoing activity in this network.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology [discontinued] 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > UPD Murtenstrasse |
UniBE Contributor: |
König, Thomas, van Swam, Claudia Jana, Dierks, Thomas, Hubl, Daniela |
ISSN: |
0920-9964 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:38 |
Last Modified: |
02 Mar 2023 23:21 |
Publisher DOI: |
10.1016/j.schres.2012.07.016 |
PubMed ID: |
22892287 |
Web of Science ID: |
000309511300025 |
BORIS DOI: |
10.7892/boris.15312 |
URI: |
https://boris.unibe.ch/id/eprint/15312 (FactScience: 222624) |
Actions (login required)
 |
Edit item |