The Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation.

Reiner, Martin F; Baumgartner, Philipp; Wiencierz, Andrea; Coslovsky, Michael; Bonetti, Nicole R; Filipovic, Mark G; Montrasio, Giulia; Aeschbacher, Stefanie; Rodondi, Nicolas; Baretella, Oliver; Kühne, Michael; Moschovitis, Giorgio; Meyre, Pascal; Bonati, Leo H; Lüscher, Thomas F; Camici, Giovanni G; Osswald, Stefan; Conen, David; Beer, Jürg H (2021). The Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation. Nutrients, 13(2), p. 651. Molecular Diversity Preservation International MDPI 10.3390/nu13020651

[img]
Preview
Text
Reiner__Nutrients_2021.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (233kB) | Preview

The omega-3 fatty acid (n-3 FA) eicosapentaenoic acid (EPA) reduces stroke in patients with atherosclerotic cardiovascular disease. Whether EPA affects stroke or cerebral small vessel dis-ease in patients with atrial fibrillation (AF) remains uncertain. EPA, docosahexaenoic acid (DHA), docosapentaenoic acid (DPA), and alpha-linolenic acid (ALA) were determined by gas chromatography in 1657 AF patients from the Swiss Atrial Fibrillation study. All patients underwent brain MRI to detect ischemic brain infarcts, classified as large noncortical or cortical infarcts (LNCCIs); markers of small vessel disease, classified as small noncortical infarcts (SNCIs), number of microbleeds, and white matter lesion (WML) volumes. Individual and total n-3 FAs (EPA + DHA + DPA + ALA) were correlated with LNCCIs and SNCIs using logistic regression, with numbers of microbleeds using a hurdle model, and WML volumes using linear regression. LNCCIs were detected in 372 patients (22.5%). EPA correlated inversely with the prevalence of LNCCIs (odds ratio [OR] 0.51 per increase of 1 percentage point EPA, 95% confidence interval [CI] 0.29-0.90). DPA correlated with a higher LNCCI prevalence (OR 2.48, 95%CI 1.49-4.13). No associations with LNCCIs were found for DHA, ALA, and total n-3 FAs. Neither individual nor total n-3 FAs correlated with markers of small vessel disease. In conclusion, EPA correlates inversely with the prevalence of ischemic brain infarcts, but not with markers of small vessel disease in patients with AF.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine
04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM)
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine

UniBE Contributor:

Rodondi, Nicolas and Baretella, Oliver

Subjects:

300 Social sciences, sociology & anthropology > 360 Social problems & social services
600 Technology > 610 Medicine & health

ISSN:

2072-6643

Publisher:

Molecular Diversity Preservation International MDPI

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Tobias Tritschler

Date Deposited:

15 Mar 2021 12:20

Last Modified:

07 Sep 2021 17:17

Publisher DOI:

10.3390/nu13020651

PubMed ID:

33671288

Uncontrolled Keywords:

atrial fibrillation brain ischemia eicosapentaenoic acid omega-3 fatty acids stroke

BORIS DOI:

10.48350/153363

URI:

https://boris.unibe.ch/id/eprint/153363

Actions (login required)

Edit item Edit item
Provide Feedback