Improving tumor budding reporting in colorectal cancer: a Delphi consensus study.

Haddad, Tariq Sami; Lugli, Alessandro; Aherne, Susan; Barresi, Valeria; Terris, Benoît; Bokhorst, John-Melle; Brockmoeller, Scarlet Fiona; Cuatrecasas, Miriam; Simmer, Femke; El-Zimaity, Hala; Fléjou, Jean-François; Gibbons, David; Cathomas, Gieri; Kirsch, Richard; Kuhlmann, Tine Plato; Langner, Cord; Loughrey, Maurice B; Riddell, Robert; Ristimäki, Ari; Kakar, Sanjay; ... (2021). Improving tumor budding reporting in colorectal cancer: a Delphi consensus study. Virchows Archiv, 479(3), pp. 459-469. Springer 10.1007/s00428-021-03059-9

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Tumor budding is a long-established independent adverse prognostic marker in colorectal cancer, yet methods for its assessment have varied widely. In an effort to standardize its reporting, a group of experts met in Bern, Switzerland, in 2016 to reach consensus on a single, international, evidence-based method for tumor budding assessment and reporting (International Tumor Budding Consensus Conference [ITBCC]). Tumor budding assessment using the ITBCC criteria has been validated in large cohorts of cancer patients and incorporated into several international colorectal cancer pathology and clinical guidelines. With the wider reporting of tumor budding, new issues have emerged that require further clarification. To better inform researchers and health-care professionals on these issues, an international group of experts in gastrointestinal pathology participated in a modified Delphi process to generate consensus and highlight areas requiring further research. This effort serves to re-affirm the importance of tumor budding in colorectal cancer and support its continued use in routine clinical practice.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Translational Research Unit
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Lugli, Alessandro and Zlobec, Inti

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0945-6317

Publisher:

Springer

Language:

English

Submitter:

Inti Zlobec

Date Deposited:

11 Mar 2021 09:47

Last Modified:

20 Sep 2021 01:31

Publisher DOI:

10.1007/s00428-021-03059-9

PubMed ID:

33650042

Uncontrolled Keywords:

Colorectal cancer Delphi study ITBCC Tumor budding

BORIS DOI:

10.48350/153600

URI:

https://boris.unibe.ch/id/eprint/153600

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