Pre-oxygenation using high-flow nasal oxygen vs. tight facemask during rapid sequence induction.

Sjöblom, A; Broms, J; Hedberg, M; Lodenius, Å; Furubacke, A; Henningsson, R; Wiklund, A; Nabecker, S; Theiler, L; Jonsson Fagerlund, M (2021). Pre-oxygenation using high-flow nasal oxygen vs. tight facemask during rapid sequence induction. (In Press). Anaesthesia Wiley-Blackwell 10.1111/anae.15426

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Pre-oxygenation using high-flow nasal oxygen can decrease the risk of desaturation during rapid sequence induction in patients undergoing emergency surgery. Previous studies were single-centre and often in limited settings. This randomised, international, multicentre trial compared high-flow nasal oxygen with standard facemask pre-oxygenation for rapid sequence induction in emergency surgery at all hours of the day and night. A total of 350 adult patients from six centres in Sweden and one in Switzerland undergoing emergency surgery where rapid sequence induction was required were included and randomly allocated to pre-oxygenation with 100% oxygen using high-flow nasal oxygen or a standard tight-fitting facemask. The primary outcome was the number of patients developing oxygen saturations <93% from the start of pre-oxygenation until 1 min after tracheal intubation. Data from 349 of 350 patients who entered the study were analysed (174 in the high-flow nasal oxygen group and 175 in the facemask group). No difference was detected in the number of patients desaturating <93%, five (2.9%) vs. six (3.4%) patients in the high-flow nasal oxygen and facemask group, respectively (p = 0.77). The risk of desaturation was not increased during on-call hours. No difference was seen in end-tidal carbon dioxide levels in the first breath after tracheal intubation or in the number of patients with signs of regurgitation between groups. These results confirm that high-flow nasal oxygen maintains adequate oxygen levels during pre-oxygenation for rapid sequence induction.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Nabecker, Sabine


600 Technology > 610 Medicine & health








Jeannie Wurz

Date Deposited:

29 Apr 2021 14:40

Last Modified:

29 Apr 2021 14:40

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

emergency intubation oxygen desaturation pre-oxygenation rapid sequence induction




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