Hodgkin’s Lymphoma

Bürkle, Carolin; von Wolff, Michael; Behringer, Karolin (2020). Hodgkin’s Lymphoma. In: von Wolff, Michael; Nawroth, Frank (eds.) Fertility Preservation in Oncological and Non-Oncological Diseases (pp. 43-53). Cham: Springer 10.1007/978-3-030-47568-0_7

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Hodgkin’s lymphoma occurs frequently in younger age. Fertility preservation is an important issue as survival rates are very high and some of the treatments are highly gonadotoxic.

Two relevant chemotherapy protocols are performed in Hodgkin’s lymphoma: ABVD and escalated BEACOPP. Some patients also receive local radiotherapy. Risk of amenorrhoea is >20% in women ≥30 years receiving any escalated BEACOPP therapy, and in women <30 years receiving ≥6 cycles escalated BEACOPP. Oligospermia can be detected among male patients independent of chemotherapy regimens and radiation. Azoospermia depends on intensity of the chemotherapy regimen. Therefore, women and men who are treated with these regimens should be advised to undergo fertility preservation therapy. The treatments which can be offered are freezing of oocytes, freezing of ovarian tissue and GnRHa, alone or in combination, as well as freezing of sperm or testicular tissue.

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